Tianeptine

Tianeptine is an atypical tricyclic antidepressant of the dibenzothiazepine class. Unlike typical tricyclics, it is thought to act primarily through glutamatergic modulation rather than direct monoaminergic regulation. Clinically prescribed for depression and anxiety, it also exhibits anxiolytic and purported nootropic properties. At supratherapeutic doses, tianeptine produces opioid-like effects, contributing to its recreational misuse potential. It is considered habit-forming and is most commonly available in its sodium salt form.

Also known as: Zaza, Coaxil, Stablon, Tatinol, Pegasus

Classification

Chemical: Medicine
Chemical: Opioid
Psychoactive: Depressant
Psychoactive: Nootropic
Tag: Antidepressant
Tag: Dibenzothiazepine
Tag: Dibenzothiazepine derivative
Tag: Habit-Forming
Tag: Pharmaceutical
Tag: Tricyclic compound

Effects

Stimulation
Physical Euphoria
Bronchodilation
Muscle Relaxation
Headache
Physical Fatigue
Motivation Enhancement
Anxiety Suppression
Cognitive Euphoria
Focus Enhancement
Rejuvenation
Cognitive Fatigue
Internal Hallucination
Dulled Perception
Dehydration
Appetite Change
Entity Imagery
Open Eye Visuals

Routes of Administration

Oral

Dosage

Heavy: 100 mg
Light: 3 – 12 mg
Common: 12 – 35 mg
Strong: 35 – 100 mg
Threshold: 3 mg

Duration

Onset: 0.5-1 h
Comeup: 0.25-0.5 h
Peak: 1-1.5 h
Offset: 0.5-1 h
After Effects: 1-8 h

Harm Reduction

Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.

Sources

Substance data is aggregated from the following public harm-reduction and reference sources.

Links

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