Adinazolam is a short-acting triazolobenzodiazepine originally investigated as both an anxiolytic and antidepressant but never FDA approved. In clinical trials (10-90 mg/day) it showed rapid relief of anxiety and modest antidepressant efficacy comparable to tricyclics with fewer anticholinergic effects. Human studies found adinazolam causes the most mental and physical sedation compared to diazepam and lorazepam, along with significant mental unpleasantness. Recreationally it produces a calm effect with less amnesia than diazepam, though individual reports vary. Because of its short half-life, interdose rebound anxiety is common and redosing drives escalation.
Adinazolam molecular structure diagram from the DrugsPRO substance library.
Also known as: Deracyn, U-41,123, Adinazolamum
Classification
Chemical: Benzodiazepine
Psychoactive: Depressant
Tag: Anxiolytic
Tag: GABAergic
Tag: Habit-Forming
Tag: Muscle Relaxant
Tag: Tentative
Effects
Sedation
Muscle Relaxation
Physical Euphoria
Respiratory Depression
Incoordination
Impaired Balance
Anxiety Suppression
Cognitive Impairment
Motor Control Loss
Memory Suppression
Thought Deceleration
Euphoria
Disinhibition
Dulled Perception
Routes of Administration
Oral
Dosage
Threshold: <5 mg
Light: 5 – 15 mg
Common: 15 – 30 mg
Strong: 30 – 50 mg
Heavy: >50 mg
Duration
Onset: 0.17-0.42 h
Peak: 1-2 h
Offset: 1.5-3 h
After Effects: 4-16 h
Total Duration: 2-8 h
Sublingual
Dosage
Threshold: <3 mg
Light: 3 – 10 mg
Common: 10 – 20 mg
Strong: 20 – 35 mg
Heavy: >35 mg
Duration
Onset: 0.17-0.42 h
Peak: 0.75-2 h
Offset: 1.5-3 h
After Effects: 4-16 h
Total Duration: 2-7 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Adinazolam - Treoir substaint DrugsPRO
Adinazolam: Adinazolam is a short-acting triazolobenzodiazepine originally investigated as both an anxiolytic and antidepressant but never FDA approved. In clinical trials (10-90 mg/day) it showed rapid relief of anxiety and modest antidepressant efficacy comparable to tricyclics with fewer antichol
