Bufotenin (5-HO-DMT, N,N-dimethylserotonin, bufotenine) is a naturally occurring substituted tryptamine alkaloid and a serotonergic psychedelic drug. Bufotenin is a structural derivative of tryptamine and serotonin. Bufotenin is found in a wide array of flora and fauna, including several species of psychoactive toads, most notably the Colorado River toad. The overall effects of bufotenin are generally described as less pleasant than those of other psychedelics such as LSD.
Búfotenín molecular structure diagram from the DrugsPRO substance library.
Also known as: 5-ho-dmt, Toad venom, Bufotenine, 5-OH-DMT, N,N-dimethylserotonin, Dimethylserotonin, Mappine, Cebilcin
Classification
Chemical: Tryptamine
Psychoactive: Psychedelic
Tag: substituted tryptamine
Effects
Nausea
Incoordination
Vomiting
Dilated Pupils
Pupil Dilation
Stimulation
Time Dilation
Anxiety
Panic
Unity Experience
Thought Loop
Memory Impairment
Closed Eye Visuals
Open Eye Visuals
Geometric Imagery
Color Enhancement
Auditory Warping
Warping
Routes of Administration
Smoked
Dosage
Threshold: 2 mg
Heavy: 60 mg
Common: 20-40 mg
Light: 5-20 mg
Strong: 40-60 mg
Duration
Onset: 0.3-1 h
Comeup: 0 h
Peak: 0-0.1 h
Offset: 0.1-0.2 h
After Effects: 0.2-1 h
Total Duration: 0.25-1 h
Insufflated
Dosage
Heavy: >60 mg
Light: 10–20 mg
Common: 20–40 mg
Strong: 40–60 mg
Threshold: 5 mg
Duration
Onset: 2-10 h
Peak: 20-40 h
Offset: 30-60 h
After Effects: 30-90 h
Total Duration: 0.75-2 h
Oral
Dosage
Heavy: >80 mg
Light: 20–35 mg
Common: 35–60 mg
Strong: 60–80 mg
Threshold: 10 mg
Duration
Onset: 0.5-1 h
Peak: 1-2 h
Offset: 1-2 h
After Effects: 2-6 h
Total Duration: 3-6 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Bufotenin - Treoir substaint DrugsPRO
Bufotenin: Bufotenin (5-HO-DMT, N,N-dimethylserotonin, bufotenine) is a naturally occurring substituted tryptamine alkaloid and a serotonergic psychedelic drug. Bufotenin is a structural derivative of tryptamine and serotonin. Bufotenin is found in a wide array of flora and fauna, including several
