MDAI was developed as a putatively non-neurotoxic MDMA analogue, but research indicates it may still cause neurotoxicity when combined with amphetamines or used chronically. Three UK deaths in 2011-2012 were linked to MDAI use with serotonin syndrome as a suspected factor. The substance should be accurately weighed on a milligram scale due to variable purity. Users should be aware that MDAI is primarily sedating rather than stimulating, lacks the dopaminergic effects of MDMA, and is often described as producing empathogenic effects without euphoric stimulation. Set and setting remain important considerations.
MDAI molecular structure diagram from the DrugsPRO substance library.
Also known as: Mindy, Sparkle
Classification
Chemical: Aminoindane
Psychoactive: Entactogen
Psychoactive: Psychedelic
Psychoactive: Stimulant
Tag: Empathogen
Tag: Habit-Forming
Tag: Research-Chemical
Tag: Serotonergic
Effects
Sedation
Physical Euphoria
Temperature Regulation Suppression
Difficulty Urinating
Nystagmus
Dilated Pupils
Anxiety Suppression
Empathy Enhancement
Sociability Enhancement
Cognitive Euphoria
Talkativeness
Alertness Enhancement
Tactile Enhancement
Music Appreciation
Spontaneous Physical Sensations
Dehydration
Light Sensitivity
Perception Of Bodily Heaviness
Routes of Administration
Oral
Dosage
Threshold: 20-40 mg
Light: 40-100 mg
Common: 100-175 mg
Strong: 175-300 mg
Heavy: 150-300 mg
Duration
Onset: 0.3-0.7 h
Comeup: 0.5-1 h
Peak: 2-2.5 h
Offset: 1-2 h
After Effects: 12 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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MDAI - Treoir substaint DrugsPRO
MDAI: MDAI was developed as a putatively non-neurotoxic MDMA analogue, but research indicates it may still cause neurotoxicity when combined with amphetamines or used chronically. Three UK deaths in 2011-2012 were linked to MDAI use with serotonin syndrome as a suspected factor. The substance should
