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PMA

PMA is extremely dangerous and notorious for its high toxicity and risk of fatal overdose at doses only slightly above the common range. It is often mis-sold as MDMA or ecstasy but is significantly more toxic, causing hyperthermia, hypertension, and serotonin syndrome. PMA has a slower onset than MDMA (30-60 minutes vs 20-40 minutes), leading users to redose before effects are felt, resulting in accidental overdose. Deaths have occurred at doses as low as 60-80 mg. PMA is 5-10 times more potent than MDMA and acts as both a serotonin releaser and MAO-A inhibitor.

PMA molecular structure
PMA molecular structure diagram from the DrugsPRO substance library.

Also known as: 4-ma, Death, 4-meoa, Killer, 4-meoma, Para-methoxyamphetamine, 4-methoxyamphetamine

Classification

  • Chemical: Amphetamine
  • Chemical: Phenethylamine
  • Psychoactive: Entactogen
  • Psychoactive: Psychedelic
  • Psychoactive: Stimulant
  • Tag: Extremely dangerous
  • Tag: Hallucinogen
  • Tag: Research-Chemical
  • Tag: Substituted amphetamine
  • Tag: Tentative

Effects

  • Stimulation
  • Abnormal Heartbeat
  • Increased Bodily Temperature
  • Increased Blood Pressure
  • Increased Heart Rate
  • Increased Perspiration
  • Dizziness
  • Anxiety
  • Time Distortion
  • Wakefulness
  • Empathy Enhancement
  • Apprehension
  • Appetite Suppression
  • Dehydration
  • Vibrating Vision
  • Cognitive Dysphoria
  • Visual Drifting
  • Open Eye Visuals

Routes of Administration

Oral

Dosage

  • Threshold: 5-10 mg
  • Light: 10-20 mg
  • Common: 100-120 mg
  • Strong: 120 mg
  • Heavy: 120 mg

Duration

  • Onset: 0.75-1.5 h
  • Comeup: 1-2 h
  • Peak: 2-5 h
  • Offset: 6-14 h
  • After Effects: 12-24 h
  • Total Duration: 6-24 h

Harm Reduction

Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.

Sources

Substance data is aggregated from the following public harm-reduction and reference sources.

Links

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PMA - Treoir substaint DrugsPRO

PMA: PMA is extremely dangerous and notorious for its high toxicity and risk of fatal overdose at doses only slightly above the common range. It is often mis-sold as MDMA or ecstasy but is significantly more toxic, causing hyperthermia, hypertension, and serotonin syndrome. PMA has a slower onset th

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