Tiletamine is typically supplied as the veterinary anaesthetic Telazol (1:1 with zolazepam); pure API crystals now circulate on the grey market and are at least 2-3x the potency of ketamine by weight. Human pharmacokinetics are poorly studied, but polar bear and porcine data place the elimination half-life at approximately 1.8 hours with rapid hepatic N-deethylation. Nasal administration burns sharply due to low pH, so users dilute in 0.9% saline or switch to IM for harm reduction. Repeated use has produced prolonged tremor syndromes, cerebellar ataxia, choreiform movements and week-long cognitive depersonalisation even at doses under 30 mg insufflated. Forum consensus caps single doses at 30 mg or below and total session load at 60 mg or below to minimise neuro-excitation.
Tíleatamín molecular structure diagram from the DrugsPRO substance library.
Also known as: O-tce, Ci-634, Cl-399, Telazol, Zoletil, Tiletaminum
Classification
Chemical: Arylcyclohexylamine
Psychoactive: Depressant
Psychoactive: Dissociative
Tag: Habit-Forming
Tag: Research-Chemical
Tag: Tentative
Effects
Physical Disconnection
Anesthesia
Nystagmus
Muscle Spasms
Somatic Lightness
Incoordination
Cognitive Disconnection
Depersonalization
Derealization
Motor Control Loss
Euphoria
Time Distortion
Visual Disconnection
Tactile Suppression
Auditory Hallucination
Immersive Dissociative Geometry
Internal Auditory Phenomena
Dulled Perception
Routes of Administration
Oral / Sublingual
Dosage
Threshold: 5 mg
Light: 5-12 mg
Common: 12-30 mg
Strong: 30-45 mg
Heavy: 45 mg
Duration
Onset: 0.25-0.5 h
Comeup: 0.5-0.75 h
Peak: 0.5-1.5 h
Offset: 1-2 h
After Effects: 4-24 h
Insufflated
Dosage
Threshold: 2 mg
Light: 2-7 mg
Common: 7-20 mg
Strong: 20-35 mg
Heavy: 35 mg+
Duration
Onset: 0.08-0.17 h
Comeup: 0.17-0.33 h
Peak: 0.5-1.5 h
Offset: 1.5-2.5 h
After Effects: 4-24 h
Total Duration: 2-4 h
Intramuscular
Dosage
Threshold: 2 mg
Light: 2.5-5 mg
Common: 5-12 mg
Strong: 10-20 mg
Heavy: 20 mg+
Duration
Onset: 0.03-0.08 h
Comeup: 0.08-0.17 h
Peak: 0.5-1.5 h
Offset: 1.5-2.5 h
After Effects: 4-24 h
Total Duration: 2-4 h
Rectal
Dosage
Threshold: 5 mg
Light: 5-15 mg
Common: 15-25 mg
Strong: 25-40 mg
Heavy: 40 mg+
Duration
Onset: 0.08-0.25 h
Comeup: 0.25-0.5 h
Peak: 0.5-1.5 h
Offset: 1.5-2.5 h
After Effects: 4-24 h
Total Duration: 2-4 h
Oral
Dosage
Common: 25-50 mg
Light: 10-25 mg
Strong: 50-100 mg
Heavy: 100+ mg
Threshold: 5 mg
Duration
Onset: 0.25-0.5 h
Peak: 0.75-1.5 h
Offset: 2-3 h
After Effects: 4-24 h
Total Duration: 2.5-5 h
Sublingual
Dosage
Heavy: 40 mg+
Light: 5–12 mg
Common: 12–25 mg
Strong: 25–40 mg
Threshold: 5 mg
Duration
No data available for this section yet.
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Tiletamine - Treoir substaint DrugsPRO
Tiletamine: Tiletamine is typically supplied as the veterinary anaesthetic Telazol (1:1 with zolazepam); pure API crystals now circulate on the grey market and are at least 2-3x the potency of ketamine by weight. Human pharmacokinetics are poorly studied, but polar bear and porcine data place the el
