Tramadol

Tramadol is a synthetic opioid analgesic of the phenylpropylamine class, structurally related to codeine and morphine. Developed in 1962 by German pharmaceutical company Grünenthal GmbH and launched commercially in 1977, it is widely prescribed for moderate to moderately severe pain. Tramadol is distinguished by its atypical dual mechanism, acting as both a weak μ-opioid receptor agonist and a serotonin-norepinephrine reuptake inhibitor (SNRI), with roughly one-tenth the potency of morphine. It is listed among the WHO's Essential Medicines.

Also known as: Tram, Qdolo, Tadol, Ultram, Tramal, Ultracet, Tramadolum

Classification

Chemical: Medicine
Chemical: Opioid
Psychoactive: Depressant
Tag: Common
Tag: Habit-Forming
Tag: Phenylpropylamine
Tag: Phenylpropylaminopentane

Effects

Pain Relief
Physical Euphoria
Itchiness
Stimulation
Cough Suppression
Difficulty Urinating
Cognitive Euphoria
Anxiety Suppression
Compulsive Redosing
Euphoria
Overall Feeling Of Contentedness
Drowsiness
Blurred Vision
Disinhibition
Auditory Hallucination
Internal Music
Sound Amplification
Taste Distortion

Routes of Administration

Oral

Dosage

Heavy: 250-400 mg
Light: 25 – 100 mg
Common: 100 – 150 mg
Strong: 150 – 200 mg
Threshold: 25 mg

Duration

Onset: 0.25-2 h
Comeup: 0.5-1 h
Peak: 2-6 h
Offset: 2-4 h
After Effects: 1-24 h
Total Duration: 6-14 h

Harm Reduction

Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.

Sources

Substance data is aggregated from the following public harm-reduction and reference sources.

Links

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