Zolpidem is a nonbenzodiazepine hypnotic of the imidazopyridine class, first approved by the FDA in 1992 for the treatment of insomnia. It acts at the GABA-BZ receptor complex, sharing pharmacological properties with benzodiazepines while producing comparatively less anxiolysis, muscle relaxation, and anticonvulsant activity. At higher doses, zolpidem can produce realistic hallucinations resembling those of deliriants, significant amnesia, and marked disinhibition.
Zolpidem molecular structure diagram from the DrugsPRO substance library.
Also known as: Ambien, Edluar, Stilnox, Stilnoct, Sublinox, Ambien CR, Intermezzo, Zolpimist, Stilnox CR, Ivedal, Hypnogen, Nimadorm, Zolsana, Zoltis
Classification
Chemical: Medicine
Chemical: Z-drug
Psychoactive: Depressant
Psychoactive: Psychedelic
Tag: Atypical Hallucinogen
Tag: Common
Tag: Habit-Forming
Tag: Hallucinogen
Tag: Imidazopyridine
Tag: Sedative
Tag: Z-drug
Effects
Sedation
Helps With Insomniasleep
Muscle Relaxation
Nausea
Respiratory Depression
Incoordination
Delusion
Euphoria
Anxiety Suppression
Amnesia
Dizziness
Motor Control Loss
Increased Libido
Decreased Libido
Disinhibition
Internal Hallucination
External Hallucination
Hallucinations Through All Physical Senses
Routes of Administration
Oral
Dosage
Heavy: 20-30 mg
Light: 2.5 – 5 mg
Common: 5 – 10 mg
Strong: 10 – 20 mg
Threshold: 2.5 mg
Duration
Onset: 0.25-0.75 h
Comeup: 0.5-0.75 h
Peak: 3-6 h
Offset: 4-5 h
After Effects: 6-12 h
Total Duration: 6-8 h
Sublingual
Dosage
Heavy: 5+ mg
Light: 1.75 mg
Common: 1.75-3.5 mg
Strong: 3.5-5 mg
Threshold: 1 mg
Duration
Onset: 0.17-0.5 h
Peak: 0.75-1.5 h
Offset: 2-4 h
After Effects: 2-8 h
Total Duration: 2-4 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Zolpidem - Treoir substaint DrugsPRO
Zolpidem: Zolpidem is a nonbenzodiazepine hypnotic of the imidazopyridine class, first approved by the FDA in 1992 for the treatment of insomnia. It acts at the GABA-BZ receptor complex, sharing pharmacological properties with benzodiazepines while producing comparatively less anxiolysis, muscle rel
