2-MA was investigated as an anorectic in the 1950s and is approximately one-tenth as potent as dextroamphetamine by weight. Modern knowledge comes almost entirely from research-chemical circles. Users report a functional, relatively clean stimulation with muted euphoria compared to amphetamine, though higher doses can induce anxiety, vasoconstriction, and tremor. Being an ortho-methyl analogue, it appears to have minimal serotonergic activity. Conservative dosing (spaced at least 4-6 hours), active cooling, and hydration are strongly advised.
Also known as: Ortetamine, 2-MeA, 2-Me-AMP, O-Methylamphetamine, O-TAP, O-Tolylaminopropane, 2-methylamphetamine, 2-MA, 1-(2-methylphenyl)propan-2-amine
Classification
Chemical: Amphetamine
Psychoactive: Stimulant
Tag: Habit-Forming
Tag: Research-Chemical
Tag: Tentative
Effects
Stimulation
Teeth Grinding
Increased Perspiration
Increased Heart Rate
Vasoconstriction
Increased Energyalertness
Focus Enhancement
Motivation Enhancement
Euphoria
Increased Sociability
Wakefulness
Anxiety
Appetite Suppression
Increased Libido
Increased Sexuality
Visual And Auditory Hallucinations
Open Eye Visuals
Light Sensitivity
Routes of Administration
Oral
Dosage
Threshold: 5 – 10 mg
Light: 10 – 25 mg
Common: 25 – 40 mg
Strong: 40 – 60 mg
Heavy: 60+ mg
Duration
Onset: 0.25-0.5 h
Comeup: 0.5-1 h
Peak: 1-2.5 h
Offset: 2-4 h
After Effects: 1-10 h
Total Duration: 4-8 h
Insufflated
Dosage
Threshold: 5 – 10 mg
Light: 10 – 30 mg
Common: 30 – 50 mg
Strong: 50 – 70 mg
Heavy: 70+ mg
Duration
Onset: 0.083-0.25 h
Comeup: 0.25-0.5 h
Peak: 0.5-1.5 h
Offset: 2-4 h
After Effects: 1-10 h
Total Duration: 3-6 h
Rectal
Dosage
Threshold: 5 – 10 mg
Light: 10 – 20 mg
Common: 20 – 35 mg
Strong: 35 – 50 mg
Heavy: 50+ mg
Duration
Onset: 0.05-0.17 h
Comeup: 0.17-0.33 h
Peak: 1-2.5 h
Offset: 2-4 h
After Effects: 1-10 h
Total Duration: 4-8 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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2-MA - מדריך חומרים של DrugsPRO
2-MA: 2-MA was investigated as an anorectic in the 1950s and is approximately one-tenth as potent as dextroamphetamine by weight. Modern knowledge comes almost entirely from research-chemical circles. Users report a functional, relatively clean stimulation with muted euphoria compared to amphetamine
