אמפקלורל

Amfecloral was marketed in the 1960s-70s as the anorectic Acutran and withdrawn worldwide by 1973. It functions as a prodrug that hydrolyzes to approximately equimolar amounts of dextroamphetamine (and some levoamphetamine) plus chloral hydrate, producing a unique profile with milder stimulation than pure amphetamine but potential next-day grogginess from the sedative component. The chloral metabolite (trichloroethanol) is a GABAergic hypnotic that can potentiate other CNS depressants—exercise caution with alcohol, benzodiazepines, or barbiturates. Historically, it was noted for having "little to no stimulant activity" compared to other amphetamines, likely due to the powerful sedating effects of chloral hydrate. Little modern human data exists; dosage ranges are extrapolated from historic prescribing information (25 mg tablets, 1-3 times daily) and limited user reports.

Also known as: Acutran, Amphecloral, DB08924

Classification

Chemical: Amphetamine
Psychoactive: Depressant
Psychoactive: Stimulant
Tag: Habit-Forming
Tag: Research-Chemical
Tag: Sedative

Effects

Stimulation
Teeth Grinding
Dry Mouth
Increased Heart Rate
Pupil Dilation
Sedation
Wakefulness
Focus Enhancement
Motivation Enhancement
Euphoria
Thought Acceleration
Time Distortion
Appetite Suppression
Light Sensitivity
Dulled Perception

Routes of Administration

Oral

Dosage

Threshold: 10 mg
Light: 10 – 25 mg
Common: 25 – 50 mg
Strong: 50 – 75 mg
Heavy: 75 mg +

Duration

Onset: 0.5-1.5 h
Comeup: 0.5-1 h
Peak: 1.5-4 h
Offset: 2-4 h
After Effects: 6-24 h
Total Duration: 6-12 h

Harm Reduction

Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.

Sources

Substance data is aggregated from the following public harm-reduction and reference sources.

Links

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