Naloxone (commonly sold under the brand names Narcan and Evzio) is a synthetic mu-opioid antagonist of the morphinan chemical class that is widely used to reverse the effects of an acute opioid overdose. Naloxone is sold under the brand name Narcan as a nasal spray and Evzio as an auto-injector with voice instructions.
נלוקסון molecular structure diagram from the DrugsPRO substance library.
Classification
Chemical: Morphinan
Chemical: Opioid
Tag: substituted morphinan
Tag: Opioid antagonist
Tag: Antidote
Effects
No data available for this section yet.
Routes of Administration
Insufflated
Dosage
Common: 1-4 mg
Duration
Onset: 0-0.2 h
Intramuscular
Dosage
Common: 0.4-2 mg
Duration
Onset: 0 h
Intravenous
Dosage
Common: 0.4-2 mg
Duration
Onset: 0 h
Oral
Dosage
Threshold: 4 mg
Heavy: 28 mg
Common: 8-16 mg
Light: 4-8 mg
Strong: 16-28 mg
Duration
Onset: 0.1-0.2 h
Comeup: 0.3-0.7 h
Peak: 1-2 h
Offset: 0.5-1 h
After Effects: 1-12 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Naloxone - מדריך חומרים של DrugsPRO
Naloxone: Naloxone (commonly sold under the brand names Narcan and Evzio) is a synthetic mu-opioid antagonist of the morphinan chemical class that is widely used to reverse the effects of an acute opioid overdose. Naloxone is sold under the brand name Narcan as a nasal spray and Evzio as an auto-inj