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Avizafone

Avizafone (CAS 65617-86-9) is a water-soluble lysine prodrug of diazepam developed for rapid intramuscular administration in nerve-agent antidote kits. It cyclizes in plasma (t1/2 approximately 3-4 minutes) to diazepam with an elimination half-life of approximately 0.75 hours for the parent compound, while the resulting diazepam exhibits its typical 20-40 hour half-life. Community users exploit the powder's hygroscopic nature to prepare aqueous or PEG/ethanol solutions for oral dropper dosing but note variable potency (approximately 0.7-1.0x diazepam by mass) and sticky handling issues. Subjective reports describe a flat diazepam-like sedation with strong muscle relaxation yet reduced euphoria unless 50-75 mg or higher doses are taken. High doses may reveal nonlinear conversion kinetics.

Avizafone molecular structure
Avizafone molecular structure diagram from the DrugsPRO substance library.

Also known as: Pro-diazepam, RO 03-7355, Avizafone dihydrochloride

Classification

  • Chemical: Benzodiazepine
  • Psychoactive: Depressant
  • Tag: Anxiolytic
  • Tag: GABAergic
  • Tag: Research-Chemical
  • Tag: Sedative

Effects

  • Muscle Relaxation
  • Sedation
  • Physical Euphoria
  • Motor Impairment
  • Anxiety Suppression
  • Amnesia
  • Motor Control Loss
  • Emotion Suppression
  • Thought Deceleration
  • Euphoria
  • Disinhibition
  • Dulled Perception

Routes of Administration

Oral (Solution / Capsule)

Dosage

  • Threshold: 5 mg
  • Light: 5-15 mg
  • Common: 15-30 mg
  • Strong: 30-60 mg
  • Heavy: 60 mg

Duration

  • Onset: 0.25-0.75 h
  • Peak: 1-2 h
  • Offset: 3-6 h
  • After Effects: 24 h

Intramuscular

Dosage

  • Threshold: 2.5 mg
  • Light: 5-10 mg
  • Common: 10-20 mg
  • Strong: 20-30 mg
  • Heavy: 30+ mg

Duration

  • Onset: 0.08-0.25 h
  • Peak: 0.75-2 h
  • Offset: 3-6 h
  • After Effects: 12-36 h
  • Total Duration: 6-18 h

Intranasal (Experimental)

Dosage

  • Threshold: 2 mg
  • Light: 2-5 mg
  • Common: 5-10 mg
  • Strong: 10-15 mg
  • Heavy: 15 mg

Duration

  • Onset: 0.03-0.13 h
  • Peak: 1-2 h
  • Offset: 3-6 h
  • After Effects: 24 h

Oral

Dosage

  • Heavy: 60+ mg
  • Light: 5–15 mg
  • Common: 15–30 mg
  • Strong: 30–60 mg
  • Threshold: 2–5 mg

Duration

  • Onset: 0.25-1 h
  • Peak: 1-2 h
  • Offset: 3-8 h
  • After Effects: 12-48 h
  • Total Duration: 6-24 h

Insufflated

Dosage

  • Heavy: 20+ mg
  • Light: 5–10 mg
  • Common: 10–15 mg
  • Strong: 15–20 mg
  • Threshold: 2–5 mg

Duration

No data available for this section yet.

Harm Reduction

Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.

Sources

Substance data is aggregated from the following public harm-reduction and reference sources.

Links

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Avizafone - DrugsPRO vodič za tvari

Avizafone: Avizafone (CAS 65617-86-9) is a water-soluble lysine prodrug of diazepam developed for rapid intramuscular administration in nerve-agent antidote kits. It cyclizes in plasma (t1/2 approximately 3-4 minutes) to diazepam with an elimination half-life of approximately 0.75 hours for the pare

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