Pregabalin is a depressant and anxiolytic substance of the gabapentinoid class, structurally related to GABA. First synthesized in 1990 and marketed under the trade name Lyrica in 2005, it is commonly prescribed for neuropathic pain, anxiety, epilepsy, and fibromyalgia. Compared to the related compound gabapentin, pregabalin offers greater bioavailability and potency. It is also used recreationally for its reported euphoric, anxiolytic, and pro-social properties.
Pregabalin molecular structure diagram from the DrugsPRO substance library.
Also known as: Lyrica, Nervalin, Pregablin, DB00230, CI-1008, PD-144723, Α2δ calcium-channel ligand, PGB
Classification
Chemical: Gabapentinoid
Chemical: Medicine
Psychoactive: Depressant
Tag: Anticonvulsant
Tag: Anxiolytic
Tag: Common
Tag: GABA analogue
Tag: Habit-Forming
Tag: Sedative
Effects
Sedation
Pain Relief
Muscle Spasms
Respiratory Depression
Seizure Suppression
Anxiolytic
Amnesia
Motivation Enhancement
Anxiety Suppression
Thought Deceleration
Information Processing Suppression
Empathy Love And Sociability Enhancement
Disinhibition
Internal Hallucination
Acuity Enhancement
Auditory Enhancement
Color Enhancement
Double Vision
Routes of Administration
Oral
Dosage
Heavy: 600+ mg
Light: 150 – 300 mg
Common: 150 – 600 mg/day
Strong: 300 – 600 mg
Threshold: 150 mg
Duration
Onset: 0.5-1.5 h
Comeup: 1-2 h
Peak: 1.5-3 h
Offset: 4-8 h
After Effects: 4-10 h
Total Duration: 4-8 h
Rectal
Dosage
Heavy: 600+ mg
Light: 40 – 200 mg
Common: 200 – 450 mg
Strong: 450 – 600 mg
Threshold: 40 mg
Duration
Onset: 0.25-0.5 h
Comeup: 0.5-2 h
Peak: 2-3 h
Offset: 3-5 h
After Effects: 6-12 h
Insufflated
Dosage
Heavy: 400+ mg
Light: 25–75 mg
Common: 75–200 mg
Strong: 200–400 mg
Threshold: 25 mg
Duration
No data available for this section yet.
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Pregabalin - DrugsPRO vodič za tvari
Pregabalin: Pregabalin is a depressant and anxiolytic substance of the gabapentinoid class, structurally related to GABA. First synthesized in 1990 and marketed under the trade name Lyrica in 2005, it is commonly prescribed for neuropathic pain, anxiety, epilepsy, and fibromyalgia. Compared to the r
