Present only at ≈0.6 % in kratom leaf, bulk 7-OH sold today is semisynthetic. Community assays reveal large potency discrepancies between commercial tablets; verified pure material produces pronounced opioid effects at single-digit milligram doses. Users describe hydromorphone-like euphoria, rapidly waning after ≈2 h, driving frequent redosing. Withdrawal emerges after 3–5 days of daily use and is reportedly more dysphoric than kratom leaf alone. Harm-reduction advice includes starting ≤1 mg, spacing doses ≥6 h, combining with plain leaf rather than escalating 7-OH, and securing naloxone.
Also known as: 7-oh-mit, 7-hydroxy mitragynine, Mitragynine hydroxyindolenine, 9-methoxycorynantheidine hydroxyindolenine, 7-HMG, 7-OHM, 7-HO-mitragynine
Classification
Chemical: Opioid
Psychoactive: Depressant
Tag: Alkaloid
Tag: Habit-Forming
Tag: Research-Chemical
Tag: Sedative
Effects
Physical Euphoria
Sedation
Pupil Constriction
Itching
Nausea
Respiratory Depression
Dream Potentiation
Euphoria
Sadness
Reduced Anxiety
Anxiety Suppression
Cognitive Euphoria
Dulled Perception
Appetite Suppression
Dehydration
Color Enhancement
Auditory Enhancement
Internal Hallucination
Routes of Administration
Oral (Tablets / Capsules; Dissolved Powder)
Dosage
Threshold: 0.5-1 mg
Light: 1-2 mg
Common: 2-5 mg
Strong: 5-10 mg
Heavy: 10 mg
Duration
Onset: 0.08-0.25 h
Peak: 0.5-1.5 h
Offset: 1-3 h
After Effects: 2-8 h
Sublingual / Buccal
Dosage
Threshold: 0.3-0.8 mg
Light: 0.8-1.5 mg
Common: 1.5-4 mg
Strong: 4-8 mg
Heavy: 8 mg
Duration
Onset: 0.08-0.25 h
Peak: 0.5-1.5 h
Offset: 1-3 h
After Effects: 2-8 h
Oral
Dosage
Heavy: 10+ mg
Light: 1–2 mg
Common: 2–5 mg
Strong: 5–10 mg
Threshold: 0.5–1 mg
Duration
Onset: 0.25-0.5 h
Peak: 0.5-1.5 h
Offset: 1-3 h
After Effects: 2-8 h
Total Duration: 3-6 h
Sublingual
Dosage
Heavy: 8+ mg
Light: 0.8–1.5 mg
Common: 1.5–4 mg
Strong: 4–8 mg
Threshold: 0.3–0.8 mg
Duration
Onset: 0.08-0.25 h
Peak: 0.5-1.5 h
Offset: 1-3 h
After Effects: 2-8 h
Total Duration: 3-6 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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7-OH - DrugsPRO anyag útmutató
7-OH: Present only at ≈0.6 % in kratom leaf, bulk 7-OH sold today is semisynthetic. Community assays reveal large potency discrepancies between commercial tablets; verified pure material produces pronounced opioid effects at single-digit milligram doses. Users describe hydromorphone-like euphoria, r
