4-PrO-MET is marketed in Europe as pressed pellets labeled 15-20 mg; multiple user reports indicate substantial potency variability between batches, so titration from 2-3 mg is prudent. A German-language thread documents perceived microdose at 0.5-3 mg, light 4-8 mg, and 8 mg+ as very strong; half of a 15 mg pellet (approximately 7.5 mg) ranged from mild to quite strong depending on the commenter, underscoring variability in pressing and individual sensitivity. As an O-propionyl ester at the 4-position, 4-PrO-MET is expected to hydrolyze to 4-HO-MET in vivo; human data are absent, but analogous work with 4-PrO-DMT demonstrates psychedelic activity in animals and supports the prodrug model. Compared with 4-HO-MET, some users describe slightly slower onset and equal or lower mg-for-mg potency; others report unexpectedly strong visuals from a single pellet, suggesting either under- or over-filled tablets or uneven distribution of active compound. A conservative harm-reduction approach is to treat 4-PrO-MET as roughly equipotent to 4-AcO-MET and somewhat less potent than 4-HO-MET, keeping first trials at or below 5-7 mg.
Also known as: 4-propionoxy-MET, O-propionyl-4-HO-MET, O-propionyl-metocin
Classification
Chemical: Tryptamine
Psychoactive: Psychedelic
Tag: Research-Chemical
Effects
Creativity Enhancement
Nausea
Excessive Yawning
Temperature Regulation Suppression
Muscle Contractions
Physical Discomfort
Euphoria
Time Distortion
Analysis Enhancement
Conceptual Thinking
Immersion Enhancement
Thought Connectivity
Color Enhancement
Pattern Recognition Enhancement
Visual Acuity Enhancement
Drifting
Increased Music Appreciation
Contrast Enhancement
Routes of Administration
Oral
Dosage
Threshold: 2 mg
Light: 3-7 mg
Common: 7-15 mg
Strong: 15-25 mg
Heavy: 25 mg+
Duration
Onset: 0.33-1 h
Comeup: 0.5-1 h
Peak: 1-3 h
Offset: 1-2 h
After Effects: 1-6 h
Total Duration: 4-6 h
Insufflated
Dosage
Heavy: 20 mg+
Light: 5–10 mg
Common: 8–15 mg
Strong: 12–20 mg
Threshold: 2–5 mg
Duration
No data available for this section yet.
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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4-Pro-MET - DrugsPRO efnisleiðsögn
4-Pro-MET: 4-PrO-MET is marketed in Europe as pressed pellets labeled 15-20 mg; multiple user reports indicate substantial potency variability between batches, so titration from 2-3 mg is prudent. A German-language thread documents perceived microdose at 0.5-3 mg, light 4-8 mg, and 8 mg+ as very str
