Oxycodone is a semisynthetic opioid of the morphinan class, synthesized from poppy-derived thebaine. Developed in Germany in 1916 as part of efforts to improve upon existing opioids such as morphine and codeine, it entered clinical use the following year. It is widely prescribed for moderate to severe pain in both immediate and extended release formulations. Compared to other opioids, it is reportedly more stimulating and mood-elevating, contributing to its significant potential for recreational misuse.
Oxýkódon molecular structure diagram from the DrugsPRO substance library.
Also known as: Oxy, O.c, Percs, Oxyir, Roxies, Dihydrohydroxycodeinone, Oxycodonum, “Oxy”, “Oxys”, Oxycontin
Classification
Chemical: Medicine
Chemical: Morphinan
Chemical: Opioid
Psychoactive: Depressant
Tag: Common
Tag: Habit-Forming
Tag: Sedative
Tag: substituted morphinan
Effects
Pain Relief
Respiratory Depression
Sedation
Itchiness
Cough Suppression
Difficulty Urinating
Euphoria
Anxiety Suppression
Dream Potentiation
Cognitive Euphoria
Sadness
Drowsiness
Internal Hallucination
Decreased Libido
Appetite Suppression
Tactile Enhancement
Increased Music Appreciation
Pleasant Touch Amplification
Routes of Administration
Oral
Dosage
Heavy: 30+ mg
Light: 5 – 10 mg
Common: 10 – 20 mg
Strong: 20 – 30 mg
Threshold: 2.5 mg
Duration
Onset: 0.17-0.5 h
Comeup: 1-2 h
Peak: 4-6 h
Offset: 0-2 h
After Effects: 6-12 h
Total Duration: 4-6 h
Intravenous
Dosage
Heavy: 10 mg
Light: 3.33 – 5 mg
Common: 5 – 7.5 mg
Strong: 7.5 – 10 mg
Threshold: 3.33 mg
Duration
Onset: 0-0.02 h
Peak: 3-5 h
Smoked
Dosage
Threshold: 1 mg
Heavy: 35 mg
Common: 8-20 mg
Light: 1.5-8 mg
Strong: 20-35 mg
Duration
No data available for this section yet.
Insufflated
Dosage
Common: 7.5-15 mg
Light: 2.5-7.5 mg
Strong: 15-25 mg
Threshold: 1 mg
Heavy: 25+ mg
Duration
Onset: 0.08-0.25 h
Comeup: 0.33-0.67 h
Peak: 1.5-4 h
Offset: 0.75-2 h
After Effects: 4-10 h
Total Duration: 3-5 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Oxycodone - DrugsPRO efnisleiðsögn
Oxycodone: Oxycodone is a semisynthetic opioid of the morphinan class, synthesized from poppy-derived thebaine. Developed in Germany in 1916 as part of efforts to improve upon existing opioids such as morphine and codeine, it entered clinical use the following year. It is widely prescribed for moder
