Aceburic acid is rapidly hydrolyzed by plasma esterases to gamma-hydroxybutyrate (GHB) within approximately 5-10 minutes, functioning as a GHB prodrug with slightly slower onset than GBL but faster than 1,4-butanediol. Due to molecular weight differences (146 vs 104), approximately 1.4 times more mass is needed compared to GHB for equivalent effects. Oral solutions are strongly acidic (pH approximately 3) and may cause throat irritation; buffering with food-grade carbonate reduces discomfort. The narrow therapeutic window between desired effects and overdose makes precise measurement with a 0.01 g scale essential. Redosing sooner than 2 hours greatly increases overdose risk.
Also known as: G, Ghb, Xyrem, Ossibato di sodio, Xyrem, alcover, 4-acetoxybutyric acid, 4-OAc-GHB
Classification
Chemical: GHB analogue
Chemical: Medicine
Psychoactive: Depressant
Tag: Butyric acid
Tag: Common
Tag: GABA analogue
Tag: GABAergic
Tag: Habit-Forming
Tag: Γ-Hydroxy acid
Tag: Research-Chemical
Tag: Sedative
Effects
Muscle Relaxation
Sedation
Stimulation And Sedation
Respiratory Depression
Nausea
Physical Fatigue
Cognitive Euphoria
Anxiety Suppression
Empathy Enhancement
Affection Enhancement
Sociability Enhancement
Motor Control Loss
Disinhibition
Increased Libido
Spatial Disorientation
Dehydration
Dulled Perception
Open Eye Visuals
Routes of Administration
Oral / Sublingual
Dosage
Threshold: 700 mg
Light: 700-1400 mg
Common: 1400-2800 mg
Strong: 2800-4200 mg
Heavy: 4200 mg
Duration
Onset: 0.25-0.5 h
Comeup: 0.17-0.33 h
Peak: 0.5-1.5 h
Offset: 1-2 h
After Effects: 1-3 h
Rectal
Dosage
Threshold: 600 mg
Light: 600 mg - 1,200 mg
Common: 600 mg
Strong: 600 mg
Heavy: 600+ mg
Duration
Onset: 0.17-0.33 h
Comeup: 0.08-0.25 h
Peak: 0.5-1.25 h
Offset: 1-2 h
After Effects: 1-3 h
Total Duration: 2-4 h
Insufflated (Irritating)
Dosage
Threshold: 400 mg
Light: 400-900 mg
Common: 900-1800 mg
Strong: 1800-2800 mg
Heavy: 2800 mg
Duration
Onset: 0.08-0.25 h
Comeup: 0.08-0.17 h
Peak: 0.5-1.5 h
Offset: 1-2 h
After Effects: 1-3 h
Oral
Dosage
Heavy: 3.5-5 g
Light: 0.5-1 g
Common: 1-2.5 g
Strong: 2.5-4 g
Threshold: 0.5 g
Dangerous: 7 g
Duration
Onset: 0.25-0.5 h
Comeup: 0.2-0.3 h
Peak: 0.8-1.5 h
Offset: 0.2-0.5 h
After Effects: 2-4 h
Total Duration: 2.5-4 h
Sublingual
Dosage
Heavy: 700+ mg
Light: 700 mg - 1,200 mg
Common: 700 mg
Strong: 700 mg
Threshold: 700 mg
Duration
No data available for this section yet.
Insufflated
Dosage
Heavy: 900+ mg
Light: 400 mg - 900 mg
Common: 900 mg - 1,800 mg
Strong: 900 mg
Threshold: 400 mg
Duration
No data available for this section yet.
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Aceburic acid - Guida alle sostanze DrugsPRO
Aceburic acid: Aceburic acid is rapidly hydrolyzed by plasma esterases to gamma-hydroxybutyrate (GHB) within approximately 5-10 minutes, functioning as a GHB prodrug with slightly slower onset than GBL but faster than 1,4-butanediol. Due to molecular weight differences (146 vs 104), approximately 1.
