4-Bromomethcathinone (4-BMC; brephedrone) is a brominated analog of methcathinone with a unique pharmacological profile among stimulant cathinones. Laboratory studies demonstrate it acts primarily as a potent serotonin reuptake inhibitor—approximately 15-fold more effective than methcathinone at SERT—alongside serotonin-norepinephrine-dopamine releasing properties, explaining its reputation for producing empathogenic effects rather than typical stimulation. User reports consistently describe calm euphoria and antidepressant-like feelings at moderate to strong doses, with minimal physical stimulation. Energy Control harm reduction testing (2014-2016) found that only 23.4% of samples sold as 4-BMC were accurately identified, with frequent adulteration or substitution with other cathinones. Halogenated cathinones including 4-BMC possess documented neurotoxic and cytotoxic properties.
Also known as: 4-bmc, 4-bmap, Brephedrone, 4-bromo-n-methylcathinone, BrMcat, Para-Bromomethcathinone
Classification
Chemical: Amphetamine
Chemical: Cathinone
Chemical: Phenethylamine
Psychoactive: Entactogen
Psychoactive: Stimulant
Tag: Research-Chemical
Tag: Synthetic cathinone
Effects
Stimulation
Physical Euphoria
Increased Energy
Pupil Dilation
Teeth Grinding
Increased Perspiration
Euphoria
Empathy Enhancement
Sociability Enhancement
Emotion Enhancement
Anxiety Suppression
Cognitive Euphoria
Increased Music Appreciation
Disinhibition
Music Enhancement
Color Enhancement
Appetite Suppression
Music Sensory Enhancement
Routes of Administration
Oral
Dosage
Threshold: 20-30 mg
Light: 20-50 mg
Common: 50-100 mg
Strong: 100-150 mg
Heavy: 250+ mg
Duration
Onset: 0.33-0.75 h
Comeup: 0.5-0.75 h
Peak: 1-2 h
Offset: 2-3.5 h
After Effects: 3.5-9.5 h
Total Duration: 3-5 h
Insufflated
Dosage
Threshold: ~20 mg
Light: 20-60 mg
Common: 60-120 mg
Strong: 120-150 mg
Heavy: 150+ mg
Duration
Onset: 0.083-0.167 h
Comeup: 0.33-0.5 h
Peak: 0.5-1 h
Offset: 1-2 h
After Effects: 4-6 h
Total Duration: 2-3 h
Rectal
Dosage
Threshold: 20 mg
Light: 20-75 mg
Common: 75-150 mg
Strong: 150-200 mg
Heavy: 200 mg
Duration
Onset: 0.25-0.5 h
Comeup: 0.5-0.75 h
Peak: 1-2 h
Offset: 1-2 h
After Effects: 1-3 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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4-Bromomethcathinone - DrugsPRO substancijos vadovas
4-Bromomethcathinone: 4-Bromomethcathinone (4-BMC; brephedrone) is a brominated analog of methcathinone with a unique pharmacological profile among stimulant cathinones. Laboratory studies demonstrate it acts primarily as a potent serotonin reuptake inhibitor—approximately 15-fold more effective tha
