4-MPD is the para-methyl analogue of pentedrone and a higher homologue of mephedrone. It appears as an off-white crystalline powder, soluble in water and ethanol; aqueous solutions degrade within days due to β-keto hydrolysis - store dry, airtight and cool. Acts primarily as a DAT and NET reuptake inhibitor with partial SERT substrate activity. Typical acute adverse effects include tachycardia (100-130 bpm), hypertension (>140/95 mmHg), jaw clenching, peripheral vasoconstriction and hyperthermia. A fatal poly-intoxication case in a chemsex context (plasma 4-MPD 1285 ng/mL) has been documented.
Also known as: 4-methylpentedrone, Para-methyl pentedrone, P-methyl pentedrone
Classification
Chemical: Cathinone
Psychoactive: Stimulant
Tag: Habit-Forming
Tag: Research-Chemical
Tag: Tentative
Effects
Stimulation
Teeth Grinding
Sweating
Vasoconstriction
Restlessness
Insomnia
Euphoria
Increased Sociability
Mild Empathy
Enhanced Music Appreciation
Anxiety
Paranoia
Sexual Arousal
Appetite Suppression
Increased Music Appreciation
Increased Libido
Light Sensitivity
Routes of Administration
Oral
Dosage
Threshold: 15-25 mg
Light: 40-80 mg
Common: 80-180 mg
Strong: 180-275 mg
Heavy: 275+ mg
Duration
Onset: 0.17-0.5 h
Comeup: 0.25-0.5 h
Peak: 0.8-2 h
Offset: 2-3.5 h
After Effects: 3.5-7 h
Total Duration: 3-5 h
Insufflated
Dosage
Threshold: 5-10 mg
Light: 15-25 mg
Common: 25-60 mg
Strong: 60-90 mg
Heavy: 90+ mg
Duration
Onset: 0.03-0.17 h
Comeup: 0.08-0.25 h
Peak: 0.5-1.5 h
Offset: 1-2 h
After Effects: 1-4 h
Total Duration: 2-4 h
Vaporized
Dosage
Threshold: 2-5 mg
Light: 5-15 mg
Common: 15-35 mg
Strong: 35-60 mg
Heavy: 60+ mg
Duration
Onset: 0-0.02 h
Comeup: 0.02-0.08 h
Peak: 0.17-0.75 h
Offset: 0.75-1.5 h
After Effects: 1.5-5 h
Total Duration: 1.5-3 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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4-MPD - DrugsPRO substancijos vadovas
4-MPD: 4-MPD is the para-methyl analogue of pentedrone and a higher homologue of mephedrone. It appears as an off-white crystalline powder, soluble in water and ethanol; aqueous solutions degrade within days due to β-keto hydrolysis - store dry, airtight and cool. Acts primarily as a DAT and NET reu
