Animal studies show markedly lower serotonergic neurotoxicity than p-iodoamphetamine, but single 40 mg/kg doses still reduced hippocampal 5-HT uptake sites. Human anecdotal reports indicate 5-IAI is less euphoric and stimulating than MDMA, with some users reporting dysphoria, anxiety, and hallucinations at various doses. Many products sold as 5-IAI between 2010-2013 were mislabeled or adulterated; reagent testing is essential. Strong jaw tension, mild hyperthermia and pronounced pupil dilation are common. Hydration, cool environment, and magnesium can reduce bruxism.
Also known as: 5-iodo-2-aminoindan, NRG-5
Classification
Chemical: Aminoindane
Psychoactive: Entactogen
Psychoactive: Psychedelic
Psychoactive: Stimulant
Tag: Empathogen
Tag: Habit-Forming
Tag: Research-Chemical
Effects
Stimulation
Teeth Grinding
Pupil Dilation
Increased Perspiration
Increased Energyalertness
Decreased Need For Sleep
Empathy And Sociability
Emotion Enhancement
Talkativeness
Dysphoria
Anxiety
Cognitive Enhancement
Tactile Enhancement
Music Enhancement
Visual Enhancement
Appetite Suppression
Dehydration
Increased Sexuality
Routes of Administration
Oral
Dosage
Threshold: 40 mg
Light: 50-100 mg
Common: 100-200 mg
Strong: 200-300 mg
Heavy: ≥300 mg
Duration
Onset: 0.33-0.75 h
Comeup: 0.5-1 h
Peak: 1-2.5 h
Offset: 2-3 h
After Effects: 1-24 h
Total Duration: 2-6 h
Insufflated
Dosage
Threshold: 20 mg
Light: 30-60 mg
Common: 60-120 mg
Strong: 120-180 mg
Heavy: ≥180 mg
Duration
Onset: 0.08-0.25 h
Comeup: 0.25-0.5 h
Peak: 0.75-2 h
Offset: 2-3 h
After Effects: 1-24 h
Total Duration: 2-5 h
Rectal
Dosage
Threshold: 30 mg
Light: 40-80 mg
Common: 80-150 mg
Strong: 150-220 mg
Heavy: ≥220 mg
Duration
Onset: 0.17-0.33 h
Comeup: 0.33-0.67 h
Peak: 1-2.5 h
Offset: 1.5-3 h
After Effects: 1-24 h
Total Duration: 2.5-6 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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5-IAI - DrugsPRO substancijos vadovas
5-IAI: Animal studies show markedly lower serotonergic neurotoxicity than p-iodoamphetamine, but single 40 mg/kg doses still reduced hippocampal 5-HT uptake sites. Human anecdotal reports indicate 5-IAI is less euphoric and stimulating than MDMA, with some users reporting dysphoria, anxiety, and hal
