Desmethylflunitrazepam is a benzodiazepine that occurs naturally as a metabolite of flunitrazepam and has been distributed as a designer drug and research chemical. It acts on the GABAA receptor, producing sedative, anxiolytic, and muscle relaxant effects typical of its class. As an understudied research chemical derived from a notably potent parent compound, its safety profile and long-term risks remain poorly characterized.
Desmetilflunitrazepamas molecular structure diagram from the DrugsPRO substance library.
Also known as: Fonazepam, Ro05-4435, Norflunitrazepam, N-desmethylflunitrazepam, Ro 5‑4435
Classification
Chemical: Benzodiazepine
Psychoactive: Depressant
Tag: Anxiolytic
Tag: GABAergic
Tag: Habit-Forming
Tag: Muscle Relaxant
Tag: Research-Chemical
Tag: Sedative
Effects
Sedation
Muscle Relaxation
Incoordination
Impaired Balance
Insomnia
Anxiety Suppression
Thought Deceleration
Amnesia
Drowsiness
Euphoria
Memory Impairment
Disinhibition
Blurred Vision
Dulled Perception
Routes of Administration
Oral
Dosage
Heavy: 3+ mg
Light: 0.25 – 0.75 mg
Common: 0.75 – 1.5 mg
Strong: 1.5 – 3 mg
Threshold: 0.25 mg
Duration
Onset: 0.33-1 h
After Effects: 12-24 h
Peak: 2-4 h
Offset: 6-10 h
Total Duration: 8-14 h
Sublingual
Dosage
Heavy: 2+ mg
Light: 0.2 – 0.5 mg
Common: 0.5 – 1 mg
Strong: 1 – 2 mg
Threshold: 0.2 mg
Duration
Onset: 0.25-0.75 h
Peak: 2-3.5 h
Offset: 5-9 h
After Effects: 10-24 h
Total Duration: 7-12 h
Insufflated
Dosage
Heavy: 2+ mg
Light: 0.2 – 0.5 mg
Common: 0.5 – 1 mg
Strong: 1 – 2 mg
Threshold: 0.2 mg
Duration
Onset: 0.08-0.33 h
Peak: 1.5-3 h
Offset: 4-8 h
After Effects: 8-20 h
Total Duration: 6-10 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
This static page is intended as a readable non-JS and prerender-friendly library export.
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Desmethylflunitrazepam - DrugsPRO substancijos vadovas
Desmethylflunitrazepam: Desmethylflunitrazepam is a benzodiazepine that occurs naturally as a metabolite of flunitrazepam and has been distributed as a designer drug and research chemical. It acts on the GABAA receptor, producing sedative, anxiolytic, and muscle relaxant effects typical of its class
