DMT is a naturally occurring psychedelic of the tryptamine class, found widely throughout the plant and animal kingdoms, including in trace amounts in humans. Richard Manske first synthesized it in 1931, and South American entheogenic traditions have used it for millennia. When vaporized, DMT produces an exceptionally intense but brief psychedelic experience. It can also be taken orally alongside a monoamine oxidase inhibitor, as in traditional ayahuasca preparations.
DMT molecular structure diagram from the DrugsPRO substance library.
Also known as: Dmitry, Dimitri, N,n-dmt, Fantasia, The glory, N,N-Dimethyltryptamine, The Spirit Molecule
Classification
Chemical: Tryptamine
Psychoactive: Psychedelic
Tag: Common
Tag: Hallucinogen
Tag: Plant-based
Tag: substituted tryptamine
Effects
Spontaneous Tactile Sensations
Stomach Discomfort
Physical Euphoria
Pupil Dilation
Temperature Regulation Suppression
Physical Discomfort
Rejuvenation
Ego Suppression Loss And Death
Enhanced Pattern Recognition
Immersive Experience
Radical Perspective Shifting
Profound Lifechanging Spiritual Experiences
Changes In Gravity
Hallucinations
Visual Drifting
Tracers
After Images
Color Shifting
Routes of Administration
Inhaled
Dosage
Heavy: 35 mg
Light: 5 – 15 mg
Common: 15 – 25 mg
Strong: 25 – 35 mg
Threshold: 5 mg
Duration
Onset: 0-0 h
Comeup: 0-0.01 h
Peak: 0.03-0.17 h
Offset: 0.02-0.1 h
After Effects: 0.25-1 h
Oral
Dosage
Heavy: 100 mg
Light: 30–50 mg DMT + 50–75 mg harmalas
Common: 50–75 mg DMT + 75–100 mg harmalas
Strong: 100+ mg DMT + 100–150 mg harmalas
Threshold: 20–30 mg DMT + 30–50 mg harmalas
Duration
Onset: 0.33-1 h
Comeup: 0.33-0.67 h
Peak: 2-3 h
Offset: 1-4 h
After Effects: 1-8 h
Total Duration: 4-8 h
Intravenous
Dosage
Heavy: 40 mg
Light: 10 – 15 mg
Common: 15 – 25 mg
Strong: 25 – 40 mg
Threshold: 10 mg
Duration
Onset: 0-0 h
Comeup: 0.02-0.03 h
Peak: 0-0.1 h
Offset: 0.17-0.33 h
Insufflated
Dosage
Common: 25-50 mg
Light: 10-25 mg
Strong: 50-125 mg
Duration
No data available for this section yet.
Vapourized
Dosage
Common: 15-25 mg
Heavy: 35 mg
Light: 10-15 mg
Strong: 25-35 mg
Threshold: 5-10 mg
Duration
No data available for this section yet.
Smoked
Dosage
Threshold: 2–5 mg
Heavy: 60+ mg
Common: 20-40 mg
Light: 10-20 mg
Strong: 40-60 mg
Duration
Onset: 0-1 h
Comeup: 0-0.1 h
Peak: 0-0.1 h
Offset: 0-0.1 h
After Effects: 0.2-1 h
Total Duration: 6-20 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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DMT - DrugsPRO substancijos vadovas
DMT: DMT is a naturally occurring psychedelic of the tryptamine class, found widely throughout the plant and animal kingdoms, including in trace amounts in humans. Richard Manske first synthesized it in 1931, and South American entheogenic traditions have used it for millennia. When vaporized, DMT p
