Codeine is a naturally occurring opiate alkaloid found in the opium poppy (*Papaver somniferum*), first discovered by Pierre Jean Robiquet in 1832. It functions primarily as a prodrug of morphine, making it a relatively weak opioid in its own right. Codeine is used medically as an analgesic, antitussive, and antidiarrheal. It is frequently available over-the-counter in combination with acetaminophen or ibuprofen, and cold water extraction is commonly employed to separate codeine from these potentially harmful additives.
Kodeīns molecular structure diagram from the DrugsPRO substance library.
Also known as: Act, Dmo
Classification
Chemical: Medicine
Chemical: Morphinan
Chemical: Opioid
Psychoactive: Depressant
Tag: Alkaloid
Tag: Common
Tag: Habit-Forming
Tag: Phenothiazine antihistamine
Tag: Sedative
Tag: substituted morphinan
Effects
Pain Relief
Physical Euphoria
Itchiness
Respiratory Depression
Sedation
Cough Suppression
Cognitive Euphoria
Anxiety Suppression
Compulsive Redosing
Dissociation
Euphoria
Motor Control Loss
Dulled Perception
Dehydration
Visual Acuity Suppression
Increased Music Appreciation
Internal Hallucination
Cognitive Dysphoria
Routes of Administration
Oral
Dosage
Heavy: 150-200 mg
Light: 50 – 100 mg
Common: 100 – 150 mg
Strong: 150 – 200 mg
Threshold: 50 mg
Duration
Onset: 0.5-0.75 h
Comeup: 1-2 h
Peak: 3-5 h
Offset: 2-4 h
After Effects: 1-12 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Codeine - DrugsPRO vielu ceļvedis
Codeine: Codeine is a naturally occurring opiate alkaloid found in the opium poppy (*Papaver somniferum*), first discovered by Pierre Jean Robiquet in 1832. It functions primarily as a prodrug of morphine, making it a relatively weak opioid in its own right. Codeine is used medically as an analgesic