Metonitazene is a high-potency synthetic benzimidazole opioid with potency similar to fentanyl (approximately 100 times morphine by central routes, 10 times orally). It has been found unexpectedly in counterfeit oxycodone pills, heroin, and other substances. Overdoses may require higher-than-normal doses of naloxone and multiple administrations to reverse. Insufflation is extremely caustic to nasal tissue (pH as low as 2). Use in combination with other depressants greatly increases the risk of fatal respiratory depression.
Metonitazēns molecular structure diagram from the DrugsPRO substance library.
Also known as: Nitazene, Metonitazine
Classification
Chemical: 2-Benzylbenzimidazole opioid
Chemical: Opioid
Psychoactive: Depressant
Tag: 2-Benzylbenzimidazole
Tag: Benzimidazole
Tag: Habit-Forming
Tag: Nitazene
Tag: Research-Chemical
Effects
Analgesia
Physical Euphoria
Sedation
Respiratory Depression
Itching
Nausea
Drowsiness
Euphoria
Sadness
Reduced Anxiety
Anxiety Suppression
Cognitive Euphoria
Warmth
Dulled Perception
Warm Flush
Appetite Suppression
Light Sensitivity
Internal Hallucination
Routes of Administration
Oral
Dosage
Threshold: <0.1 mg
Light: 0.1-0.2 mg
Common: 0.2-0.5 mg
Strong: 0.5-1 mg
Heavy: >1 mg
Duration
Onset: 0.08-0.25 h
Peak: 0.5-1.5 h
Offset: 2-4 h
Insufflated
Dosage
Threshold: <0.05 mg
Light: 0.05-0.1 mg
Common: 0.1-0.3 mg
Strong: 0.3-0.6 mg
Heavy: >0.6 mg
Duration
Onset: 0.02-0.08 h
Peak: 0.5-1.5 h
Offset: 2-4 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Metonitazene: Metonitazene is a high-potency synthetic benzimidazole opioid with potency similar to fentanyl (approximately 100 times morphine by central routes, 10 times orally). It has been found unexpectedly in counterfeit oxycodone pills, heroin, and other substances. Overdoses may require highe
