One of the most potent psychedelic tryptamines known, requiring extreme caution with dosing. Highly dose-sensitive with medical emergencies reported at doses as low as 8 mg oral. Has been misrepresented as LSD on blotter and gelatin tabs, leading to multiple hospitalizations and deaths. Always reagent-test material. Produces pronounced sympathomimetic effects including tachycardia, mydriasis, and hypertension; baseline cardiovascular health is essential.
Also known as: Alpha-o, Α,o-dms, Α,o-dimethylserotonin
Classification
Chemical: Tryptamine
Psychoactive: Entactogen
Psychoactive: Psychedelic
Psychoactive: Stimulant
Tag: 5-Methoxytryptamine
Tag: Α-Alkyltryptamine
Tag: Empathogen
Tag: Research-Chemical
Effects
Mental Stimulation
Physical Stimulation
Pupil Dilation
Restlessness
Muscle Tension
Jaw Clenching
Euphoria
Empathy Enhancement
Sociability Enhancement
Mood Elevation
Anxiety
Uncomfortable Comedown
Color Enhancement
Pattern Recognition Enhancement
Visual Patterning
Closedeye Visuals
Openeye Visuals
Auditory Enhancement
Routes of Administration
Oral
Dosage
Threshold: 0.5-1 mg
Light: 1-2 mg
Common: 2-4 mg
Strong: 4-6 mg
Heavy: 6–8+ mg
Duration
Onset: 0.5-2 h
Comeup: 1-2 h
Peak: 3-8 h
Offset: 8-14 h
After Effects: 12-24 h
Total Duration: 10-16 h
Insufflated
Dosage
Threshold: <0.5 mg
Light: 0.5-1 mg
Common: 1-2 mg
Strong: 2-3 mg
Heavy: 3+ mg
Duration
Onset: 0.08-0.33 h
Comeup: 0.33-0.67 h
Peak: 2.5-6 h
Offset: 6-12 h
After Effects: 10-24 h
Total Duration: 8-14 h
Rectal
Dosage
Threshold: 0.5 mg
Light: 0.8-1.5 mg
Common: 1.5-3 mg
Strong: 3-4 mg
Heavy: 4+ mg
Duration
Onset: 0.08-0.33 h
Comeup: 0.5-1 h
Peak: 3-8 h
Offset: 6-10 h
After Effects: 10-24 h
Total Duration: 8-12 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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5-MeO-AMT - DrugsPRO stofgids
5-MeO-AMT: One of the most potent psychedelic tryptamines known, requiring extreme caution with dosing. Highly dose-sensitive with medical emergencies reported at doses as low as 8 mg oral. Has been misrepresented as LSD on blotter and gelatin tabs, leading to multiple hospitalizations and deaths. A
