Rodent and cell data show 9-Me-BC up-regulates tyrosine hydroxylase and BDNF, promotes neurite outgrowth, and reverses rotenone/MPTP dopaminergic injury. IC50 ≈1 µM (MAO-A) and 15 µM (MAO-B) imply mild dietary tyramine sensitivity. Users report subtle but clean motivation, pattern-recognition boost, and mood brightening; bitterness limits sublingual dwell time. Common protocol: 10-20 mg daily for 14 days followed by equal washout; higher chronic doses (>40 mg) correlate with anxiety, insomnia, erectile dysfunction, or 'dirty' overstimulation. Lipophilic tissue binding gives multi-day carry-over despite plasma t½ ~2-4 h in rodents.
Also known as: 9-methyl-norharman, 9-methyl-β-carboline, 9-methyl-beta-carboline, 9‑MBC
Classification
Chemical: Beta-carboline
Chemical: Tryptamine
Psychoactive: Nootropic
Psychoactive: Psychedelic
Tag: β-carboline
Tag: Research-Chemical
Effects
Clean Mental Energy
Reduced Stimulant Tolerance
Physical Energy
Reduced Stimulant Tolerance Anecdotal
Loss Of Appetite
Spontaneous Tactile Sensations
Increased Motivation
Enhanced Working Memory
Mild Euphoria
Anxiety
Enhanced Working Memory Anecdotal
Euphoria
Appetite Suppression
Photophobia
Sexual Sideeffects
Brightness Enhancement
Sexual Dysfunction
Hallucinations
Routes of Administration
Oral
Dosage
Threshold: 5 mg
Light: 5 mg - 10 mg
Common: 10 mg - 25 mg
Strong: 25 mg - 40 mg
Heavy: 40+ mg
Duration
Onset: 0.5-1.5 h
Peak: 2-4 h
Offset: 4-10 h
After Effects: 12-24 h
Total Duration: 6-10 h
Sublingual
Dosage
Threshold: 2 mg
Light: 2 mg - 10 mg
Common: 10 mg - 25 mg
Strong: 25 mg - 35 mg
Heavy: 35+ mg
Duration
Onset: 0.17-0.5 h
Peak: 1.5-3.5 h
Offset: 3.5-9 h
After Effects: 12-24 h
Total Duration: 5-9 h
Intranasal
Dosage
Threshold: 1 mg
Light: 1-5 mg
Common: 5-15 mg
Strong: 15-25 mg
Heavy: 25 mg
Duration
Onset: 0.08-0.25 h
Peak: 2-4 h
Offset: 3-6 h
After Effects: 12-24 h
Insufflated
Dosage
Heavy: 25+ mg
Light: 1 mg - 5 mg
Common: 5 mg - 15 mg
Strong: 15 mg - 25 mg
Threshold: 1 mg
Duration
No data available for this section yet.
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
