Bufotenin is a naturally occurring tryptamine found in Anadenanthera (Yopo/Cebil) seeds and in the parotoid glands of certain Bufo and Incilius toads. The Colorado River toad (Incilius alvarius) contains primarily 5-MeO-DMT, not bufotenin, and 'toad-licking' is extremely dangerous due to cardiotoxic bufadienolides in the venom. Pure bufotenin freebase vaporizes at approximately 160°C; use low-temperature glass pipes or e-mesh devices to minimize harshness. The substance produces marked peripheral vasoconstriction, flushing, tachycardia, and has been associated with bronchospasm, especially at doses above 40 mg or when administered intravenously. Individuals with asthma, hypertension, or cardiovascular conditions should avoid use.
Bufotenin molecular structure diagram from the DrugsPRO substance library.
Also known as: Jopo, Hataj, Niopo, Cohoba, Mapine, Bufotenine, 5-HO-DMT, 5-OH-DMT, N,N-dimethylserotonin, Dimethylserotonin, Mappine, Cebilcin
Classification
Chemical: Tryptamine
Psychoactive: Psychedelic
Tag: Alkaloid
Tag: Classic-psychedelic
Tag: Entheogen
Tag: Hallucinogen
Tag: Plant-derived
Tag: Research-Chemical
Tag: substituted tryptamine
Effects
Bodily Pressures
Physical Euphoria
Skin Flushing
Vasoconstriction
Temperature Regulation Suppression
Pupil Dilation
Motor Control Loss
Recursion
Time Distortion
Thought Loop
Anxiety
Feelings Of Unity And Interconnectedness
Tactile Enhancement
Bodily Control Enhancement
Perception Of Bodily Heaviness
Visual Acuity Enhancement
Visual Acuity Suppression
Color Enhancement
Routes of Administration
Smoked
Dosage
Threshold: 2 mg
Light: 5–15 mg
Common: 15–35 mg
Strong: 35 mg
Heavy: >55 mg
Duration
Onset: 0-0.01 h
Comeup: 0-0.01 h
Peak: 0-0.1 h
Offset: 0.1-0.2 h
After Effects: 0.2-1 h
Total Duration: 15-60 h
Insufflated
Dosage
Threshold: 5 mg
Light: ~50-100 mg (seeds, pulverized)
Common: 100-200 mg (seeds, pulverized)
Strong: 200-300 mg (seeds, pulverized)
Heavy: 300 mg
Duration
Onset: 0.08-0.25 h
Comeup: 0.17-0.33 h
Peak: 0.25-0.75 h
Offset: 0.33-0.5 h
After Effects: 0.5-1.5 h
Total Duration: 45-120 h
Sublingual
Dosage
Threshold: 10 mg
Light: 20-40 mg
Common: 40-80 mg
Strong: 80-100 mg
Heavy: 100 mg
Duration
Onset: 0.08 h
Comeup: 0.17-0.33 h
Peak: 0.58-0.67 h
Offset: 0.5-1 h
After Effects: 0.5-1.5 h
Oral
Dosage
Threshold: 10 mg
Light: 20-35 mg
Common: 35-60 mg
Strong: 60-80 mg
Heavy: >80 mg
Duration
Onset: 0.5-1 h
Comeup: 0.5-1 h
Peak: 1-2 h
Offset: 1-2 h
After Effects: 2-6 h
Total Duration: 3-6 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Bufotenin - DrugsPRO stofgids
Bufotenin: Bufotenin is a naturally occurring tryptamine found in Anadenanthera (Yopo/Cebil) seeds and in the parotoid glands of certain Bufo and Incilius toads. The Colorado River toad (Incilius alvarius) contains primarily 5-MeO-DMT, not bufotenin, and 'toad-licking' is extremely dangerous due to
