Cyproheptadine

For serotonin syndrome management: administer a 12 mg oral loading dose, then 2 mg every 2 hours until clinical improvement (max 32 mg/24 hours); thereafter give 4-8 mg every 6 hours as needed. Monitor for over-sedation, urinary retention, delirium, and hepatic enzymes in prolonged courses. May interfere with hemostasis and prolong bleeding time. Not approved for use in newborns or premature infants.

Also known as: Reactin, Apeplus, Biohept, Periatin, Periactin, Peritol, Ciplactin, Cyprodine, Cyproheptadinum

Classification

Chemical: Medicine
Psychoactive: Depressant
Tag: Antihistamine
Tag: Sedative
Tag: Tricyclic benzocycloheptene

Effects

Sedation
Appetite Stimulation
Dry Mouth
Antipruritic Relief
Motor Coordination Suppression
Muscle Relaxation
Drowsiness
Relaxation
Cognitive Impairment
Calmness
Increased Appetite
Confusion
Blurred Vision
Dulled Perception
Auditory Hallucination
Cognitive Dysphoria
Perception Of Bodily Heaviness
Auditory Distortion

Routes of Administration

Oral

Dosage

Threshold: 2-4 mg
Light: 4-8 mg
Common: 8-16 mg
Strong: 16-24 mg
Heavy: 24-32 mg

Duration

Onset: 0.5-1 h
Comeup: 1-3 h
Peak: 2-6 h
Offset: 2-4 h
After Effects: 24 h

Harm Reduction

Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.

Sources

Substance data is aggregated from the following public harm-reduction and reference sources.

dose.wiki

Links

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