Flmodafinil (CRL-40,940; bisfluoromodafinil; lauflumide) is a bis(4-fluoro) derivative of modafinil with enhanced dopamine transporter affinity and improved lipophilicity. Unlike modafinil, it does not induce CYP3A4 or CYP3A5 enzymes, reducing drug-drug interactions. Animal studies demonstrate robust wake-promoting activity without classic amphetamine-like locomotor sensitisation. Human anecdotes report shorter subjective duration (6-8 hours) with crisper onset but potential late-phase anxiety spike 6-8 hours post-dose. Keeping daily use at or below 100 mg and finishing doses before 10 a.m.
Flmodafinil molecular structure diagram from the DrugsPRO substance library.
Also known as: Nls-4, Lauflumide, Crl-40,940, Bisfluoromodafinil, Fluoromodafinil, Flodafinil
Classification
Psychoactive: Nootropic
Psychoactive: Stimulant
Tag: Diphenylmethylsulfinylacetamide
Tag: Eugeroic
Tag: Research-Chemical
Tag: Tentative
Effects
Increased Heart Rate
Vasoconstriction
Stimulation
Loss Of Appetite
Insomnia
Headache
Wakefulness Enhancement
Focus Enhancement
Motivation Enhancement
Anxiety
Analysis Enhancement
Cognitive Euphoria
Appetite Suppression
Dehydration
Light Sensitivity
Photophobia
Increased Music Appreciation
Increased Libido
Routes of Administration
Oral / Sublingual
Dosage
Threshold: 15-20 mg
Light: 20-50 mg
Common: 50-100 mg
Strong: 100-150 mg
Heavy: 150 mg
Duration
Onset: 0.33-0.67 h
Comeup: 0.5-1 h
Peak: 2-4 h
Offset: 2-4 h
After Effects: 6 h
Insufflated
Dosage
Threshold: 5–10 mg
Light: 10–20 mg
Common: 15-30 mg
Strong: 30-50 mg
Heavy: 50 mg+
Duration
Onset: 0.08-0.25 h
Comeup: 0.33-0.5 h
Peak: 1.5-3.5 h
Offset: 2-4 h
After Effects: 9-15 h
Total Duration: 6-9 h
Rectal (Solution)
Dosage
Threshold: 10 mg
Light: 10-25 mg
Common: 25-60 mg
Strong: 60-90 mg
Heavy: 90 mg
Duration
Onset: 0.25-0.5 h
Comeup: 0.5-1 h
Peak: 2-4 h
Offset: 2-4 h
After Effects: 6 h
Oral
Dosage
Common: 50–100 mg
Light: 20-40 mg
Strong: 100–150 mg
Heavy: 150 mg+
Threshold: 10–20 mg
Duration
Onset: 0.33-0.67 h
Peak: 2-4 h
Offset: 6-10 h
After Effects: 10-16 h
Total Duration: 6-10 h
Sublingual
Dosage
Heavy: 120 mg+
Light: 15–40 mg
Common: 40–80 mg
Strong: 80–120 mg
Threshold: 10–15 mg
Duration
No data available for this section yet.
Rectal
Dosage
Heavy: 90 mg+
Light: 15–30 mg
Common: 30–60 mg
Strong: 60–90 mg
Threshold: 10–15 mg
Duration
No data available for this section yet.
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Flmodafinil - DrugsPRO stofgids
Flmodafinil: Flmodafinil (CRL-40,940; bisfluoromodafinil; lauflumide) is a bis(4-fluoro) derivative of modafinil with enhanced dopamine transporter affinity and improved lipophilicity. Unlike modafinil, it does not induce CYP3A4 or CYP3A5 enzymes, reducing drug-drug interactions. Animal studies demo
