Etonitazene is an extremely potent synthetic opioid discovered in 1957, approximately 1,000-1,500 times stronger than morphine in animal studies but likely 60 times stronger in humans. It was never approved for medical use due to severe dependency potential and respiratory depression. Etonitazene has an unpredictably steep dose-response curve and erratic pharmacokinetics, especially when injected, making it more hazardous than fentanyl. It has sporadically appeared in illicit drug supplies since the 1960s. Multiple doses of naloxone may be required to reverse an overdose, and renarcotization can occur as naloxone wears off.
Etonitazen molecular structure diagram from the DrugsPRO substance library.
Also known as: Ea-4941, Cs-4640, BA-20684, IDS-NE-006, NIH 7607, Benzimidazole opioid; nitazene class
Classification
Chemical: 2-Benzylbenzimidazole opioid
Chemical: Opioid
Psychoactive: Depressant
Tag: Benzimidazole
Tag: Habit-Forming
Tag: Nitazene
Tag: Research-Chemical
Effects
Physical Euphoria
Pain Relief
Sedation
Respiratory Depression
Difficulty Urinating
Itchiness
Cognitive Euphoria
Anxiety Suppression
Compulsive Redosing
Euphoria
Sadness
Drowsiness
Dulled Perception
Internal Hallucination
Size Distortion
Warmth
Warm Flush
Appetite Suppression
Routes of Administration
Oral
Dosage
No data available for this section yet.
Duration
Onset: 0.08-0.25 h
Comeup: 0.25-0.5 h
Peak: 0.5-2 h
Offset: 2-4 h
After Effects: 6-12 h
Total Duration: 4-8 h
Insufflated
Dosage
No data available for this section yet.
Duration
Onset: 0.03-0.17 h
Comeup: 0.17-0.33 h
Peak: 0.17-1 h
Offset: 1-3 h
After Effects: 4-12 h
Total Duration: 4-8 h
Intravenous
Dosage
No data available for this section yet.
Duration
Onset: 0-0.02 h
Comeup: 0.03-0.08 h
Peak: 0-0.17 h
Offset: 1.5-6 h
After Effects: 3-12 h
Total Duration: 3-6 h
Smoked
Dosage
No data available for this section yet.
Duration
Onset: 0.02-0.05 h
Comeup: 0.08-0.25 h
Peak: 0.5 h
Offset: 1-2 h
After Effects: 1-4 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Etonitazene - DrugsPRO stoffveiledning
Etonitazene: Etonitazene is an extremely potent synthetic opioid discovered in 1957, approximately 1,000-1,500 times stronger than morphine in animal studies but likely 60 times stronger in humans. It was never approved for medical use due to severe dependency potential and respiratory depression. E
