Mephedrone is a synthetic entactogen-stimulant of the substituted cathinone class. Originally synthesized in 1929, it was rediscovered in 2003 and rapidly gained popularity as an online research chemical between 2007 and 2009, particularly in the United Kingdom. Its effects are frequently compared to a combination of MDMA and cocaine. Mephedrone's short duration and intense rush are associated with compulsive redosing, and it is sometimes misrepresented as MDMA.
Also known as: Meow, 4-mmc, M-cat, 4-methylmethcathinone, Meow Meow, Drone, Bubbles
Classification
Chemical: Cathinone
Psychoactive: Entactogen
Psychoactive: Stimulant
Tag: Empathogen
Tag: Habit-Forming
Tag: Research-Chemical
Tag: Synthetic cathinone
Effects
Spontaneous Tactile Sensations
Stimulation
Difficulty Urinating
Vasoconstriction
Increased Heart Rate
Increased Perspiration
Euphoria
Thought Acceleration
Analysis Enhancement
Empathy Love And Sociability Enhancement
Time Distortion
Ego Inflation
Disinhibition
Vibrating Vision
Dehydration
Tactile Enhancement
Increased Libido
Open Eye Visuals
Routes of Administration
Oral
Dosage
Heavy: 300+ mg
Light: 15 – 50 mg
Common: 50 – 100 mg
Strong: 100 – 150 mg
Threshold: 15–25 mg
Duration
Onset: 0.25-0.75 h
Comeup: 0.25-0.5 h
Peak: 0.75-1.5 h
Offset: 0.5-1.5 h
After Effects: 2-4 h
Total Duration: 2-5 h
Insufflated
Dosage
Heavy: 125+ mg
Light: 5 – 15 mg
Common: 15 – 75 mg
Strong: 75 – 125 mg
Threshold: 5–15 mg
Duration
Onset: 0.08-0.13 h
Comeup: 0.25-0.5 h
Peak: 0.25-0.5 h
Offset: 0.5-1.5 h
After Effects: 2-4 h
Total Duration: 1-3 h
Rectal
Dosage
Heavy: 200+ mg
Light: 15–40 mg
Common: 40–100 mg
Strong: 100–200 mg
Threshold: 15–25 mg
Duration
Onset: 0.17-0.33 h
Peak: 0.33-1 h
Offset: 1-2 h
After Effects: 2-6 h
Total Duration: 2-4 h
Intravenous
Dosage
Heavy: 60+ mg
Light: 5–15 mg
Common: 15–40 mg
Strong: 40–60 mg
Threshold: 5–10 mg
Duration
Onset: 0-0.08 h
Peak: 0.08-0.5 h
Offset: 0.5-1 h
After Effects: 2-6 h
Total Duration: 1-2 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Mephedrone - DrugsPRO stoffveiledning
Mephedrone: Mephedrone is a synthetic entactogen-stimulant of the substituted cathinone class. Originally synthesized in 1929, it was rediscovered in 2003 and rapidly gained popularity as an online research chemical between 2007 and 2009, particularly in the United Kingdom. Its effects are frequentl
