Norflurazepam is a long-acting benzodiazepine and an active metabolite of several pharmaceutical benzodiazepines including flurazepam, quazepam, and midazolam. It has been available as a research chemical since 2016. Due to its extremely long half-life (47-150 hours, up to 200 hours in some individuals), it is prone to accumulation with repeated dosing and may remain detectable in the body for days after use. Fatal overdose may occur when combined with other CNS depressants. Legal status varies by jurisdiction; it is controlled in some countries including Canada (Schedule IV).
Norflurazepam molecular structure diagram from the DrugsPRO substance library.
Also known as: Norfludiazepam, N-desalkylflurazepam, N-desalkyl-2-oxoquazepam, Desalkylflurazepam, Dealkylflurazepam, Descarbethoxyloflazepate, Norflutoprazepam, Ro-05-3367, N-desalkylflutoprazepam
Classification
Chemical: Benzodiazepine
Psychoactive: Depressant
Tag: Anticonvulsant
Tag: Anxiolytic
Tag: GABAergic
Tag: Habit-Forming
Tag: Muscle Relaxant
Tag: Research-Chemical
Tag: Sedative
Tag: Tentative
Effects
Sedation
Muscle Relaxation
Incoordination
Impaired Balance
Motor Impairment
Respiratory Depression
Anxiety Suppression
Amnesia
Motor Control Loss
Cognitive Euphoria
Emotion Suppression
Thought Deceleration
Disinhibition
Dulled Perception
Open Eye Visuals
Double Vision
Blurred Vision
Voices
Routes of Administration
Oral
Dosage
Threshold: 0.5 mg
Light: 1-2 mg
Common: 5-10 mg
Strong: 10-20 mg
Heavy: 20 mg
Duration
Onset: 0.75-2 h
Comeup: 0.5-1 h
Peak: 2-4 h
Offset: 6-12 h
After Effects: 1-12 h
Total Duration: 10-16 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
This static page is intended as a readable non-JS and prerender-friendly library export.
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Norflurazepam - DrugsPRO stoffveiledning
Norflurazepam: Norflurazepam is a long-acting benzodiazepine and an active metabolite of several pharmaceutical benzodiazepines including flurazepam, quazepam, and midazolam. It has been available as a research chemical since 2016. Due to its extremely long half-life (47-150 hours, up to 200 hours i
