Mephedrone is typically sold as white or off-white powder or crystals that clump from moisture. GC-MS surveys show frequent adulteration with other cathinones; multi-reagent testing (Marquis produces no reaction or slight fizz, Liebermann gives bright yellow) plus FT-IR is recommended. It is a potent monoamine releaser with a serotonin-to-dopamine ratio of approximately 1.22:1, producing stronger stimulation and shorter duration than MDMA. Plasma half-life averages 1.5-2.1 hours with active metabolites nor-mephedrone and 4-carboxy-mephedrone; users compensate by redosing every 30-90 minutes, markedly increasing cardiovascular load and hyponatremia risk. Case reports describe acute psychosis, rhabdomyolysis, severe peripheral vasoconstriction, and necrotising skin lesions after prolonged IV use.
Also known as: Mefedron, Meow, M-cat, Bubble, Meow meow, 4-Methylmethcathinone, Drone, Bubbles
Classification
Chemical: Cathinone
Psychoactive: Entactogen
Psychoactive: Stimulant
Tag: Empathogen
Tag: Habit-Forming
Tag: Research-Chemical
Tag: Synthetic cathinone
Effects
Stimulation
Teeth Grinding
Jaw Clenching
Vasoconstriction
Increased Perspiration
Difficulty Urinating
Cognitive Euphoria
Empathy Affection And Sociability Enhancement
Motivation Enhancement
Anxiety Suppression
Time Distortion
Thought Acceleration
Increased Libido
Tactile Enhancement
Increased Music Appreciation
Disinhibition
Spontaneous Physical Sensations
Vibrating Vision
Routes of Administration
Oral
Dosage
Threshold: 15–25 mg
Light: 15 – 50 mg
Common: 50 – 100 mg
Strong: 100 – 150 mg
Heavy: 300+ mg
Duration
Onset: 0.25-0.75 h
Comeup: 0.25-0.5 h
Peak: 0.75-1.5 h
Offset: 0.5-1.5 h
After Effects: 2-4 h
Total Duration: 2-5 h
Insufflated
Dosage
Threshold: 5–15 mg
Light: 5 – 15 mg
Common: 15 – 75 mg
Strong: 75 – 125 mg
Heavy: 125+ mg
Duration
Onset: 0.08-0.13 h
Comeup: 0.25-0.5 h
Peak: 0.25-0.5 h
Offset: 0.5-1.5 h
After Effects: 2-4 h
Total Duration: 1-3 h
Rectal
Dosage
Threshold: 15–25 mg
Light: 15-40 mg
Common: 40-100 mg
Strong: 100-200 mg
Heavy: 200+ mg
Duration
Onset: 0.17-0.33 h
Comeup: 0.17-0.25 h
Peak: 0.33-1 h
Offset: 1-2 h
After Effects: 2-24 h
Total Duration: 2-4 h
Intravenous
Dosage
Threshold: 5–10 mg
Light: 5-15 mg
Common: 15-40 mg
Strong: 40-60 mg
Heavy: 60+ mg
Duration
Onset: 0-0.08 h
Comeup: 0.03-0.08 h
Peak: 0.25-0.5 h
Offset: 0.75-1.5 h
After Effects: 2-24 h
Total Duration: 1-2 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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4-MMC - przewodnik po substancji DrugsPRO
4-MMC: Mephedrone is typically sold as white or off-white powder or crystals that clump from moisture. GC-MS surveys show frequent adulteration with other cathinones; multi-reagent testing (Marquis produces no reaction or slight fizz, Liebermann gives bright yellow) plus FT-IR is recommended. It is
