Phendimetrazine is a phenmetrazine prodrug prescribed for short-term obesity management. It metabolizes into active phenmetrazine, which has known abuse potential but with slower onset than direct administration. Tolerance develops rapidly with regular use. Users should avoid combining with other appetite suppressants or stimulants. Contraindicated in cardiovascular disease, hyperthyroidism, glaucoma, and history of substance abuse.
Also known as: Pal-747, Bontril, Adipost, Appecon, Melfiat, P-Methylphenmetrazine, Para-methylphenmetrazine, 4-Me-phenmetrazine, 4-methylphenmetrazine, Mephenmetrazine
Classification
Chemical: Phenylmorpholine
Psychoactive: Entactogen
Psychoactive: Stimulant
Tag: Empathogen
Tag: Habit-Forming
Tag: Morpholine derivative
Tag: Pharmaceutical
Tag: Phenmetrazine
Tag: Research-Chemical
Tag: Tentative
Effects
Stimulation
Increased Perspiration
Increased Energy
Increased Heart Rate
Vasoconstriction
Teeth Grinding
Euphoria
Increased Sociability
Empathy
Focus Enhancement
Compulsive Redosing
Motivation Enhancement
Appetite Suppression
Tinnitus
Increased Libido
Dehydration
Ringing
Light Sensitivity
Routes of Administration
Oral (Immediate Release)
Dosage
Threshold: 10 mg
Light: 17.5-35 mg
Common: 30-70 mg
Strong: 70-120 mg
Heavy: 120 mg
Duration
Onset: 0.33-0.67 h
Comeup: 0.5-1 h
Peak: 1-2 h
Offset: 2-3 h
After Effects: 1-2 h
Oral (Extended Release)
Dosage
Threshold: 10 mg
Light: 17.5-35 mg
Common: 30-70 mg
Strong: 70-120 mg
Heavy: 120 mg
Duration
Onset: 0.33-0.67 h
Comeup: 0.5-1 h
Peak: 1-2 h
Offset: 2-3 h
After Effects: 1-2 h
Insufflated
Dosage
Threshold: 5 mg
Light: 5-20 mg
Common: 20-60 mg
Strong: 60-90 mg
Heavy: 90 mg+
Duration
Onset: 0.08-0.25 h
Comeup: 0.25-0.5 h
Peak: 0.5-1.5 h
Offset: 1.5-2.5 h
After Effects: 0.5-1.5 h
Total Duration: 3-5 h
Oral
Dosage
Heavy: 120 mg+
Light: 10-30 mg
Common: 30-70 mg
Strong: 70-120 mg
Threshold: 10 mg
Duration
Onset: 0.33-0.66 h
Peak: 1-2 h
Offset: 2-3 h
After Effects: 0.5-2 h
Total Duration: 4-6 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
This static page is intended as a readable non-JS and prerender-friendly library export.
Get the full DrugsPRO experience
Open the interactive DrugsPRO app for search, saved items, interactions, and deeper harm reduction tools.
Get the PRO test kit. The simple, quick and reliable drug checking test kit. Visit https://protestkit.eu
4-MPM - przewodnik po substancji DrugsPRO
4-MPM: Phendimetrazine is a phenmetrazine prodrug prescribed for short-term obesity management. It metabolizes into active phenmetrazine, which has known abuse potential but with slower onset than direct administration. Tolerance develops rapidly with regular use. Users should avoid combining with o
