Adderall XR uses a dual-bead system with 50% immediate-release and 50% delayed-release beads, producing bimodal pharmacokinetics. Crushing defeats the extended-release mechanism, converting it to an immediate-release preparation with higher peak plasma concentrations and increased abuse liability. Bioavailability is pH-dependent: acidic urine increases elimination rate while alkaline conditions prolong duration. Nasal insufflation of crushed beads carries risks of septal perforation and pulmonary talcosis from inert excipients. Acute toxicity includes tachyarrhythmia, hyperthermia, rhabdomyolysis, and stimulant psychosis, with risk escalating above 60 mg or with redosing within 6 hours.
Also known as: Xr, Pep, Addy, Amph
Classification
Chemical: Amphetamine
Chemical: Phenethylamine
Psychoactive: Stimulant
Tag: Common
Tag: Habit-Forming
Effects
Stimulation
Physical Euphoria
Teeth Grinding
Increased Heart Rate
Increased Blood Pressure
Vasoconstriction
Focus Enhancement
Motivation Enhancement
Cognitive Euphoria
Wakefulness
Thought Acceleration
Analysis Enhancement
Appetite Suppression
Increased Libido
Dehydration
Light Sensitivity
Routes of Administration
Oral (Immediate Release)
Dosage
Threshold: 2.5-5 mg
Light: 10-20 mg
Common: 10-30 mg
Strong: 30-60 mg
Heavy: 75-125 mg
Duration
Onset: 0.5-0.75 h
Comeup: 0.5-2.25 h
Peak: 2.5-4 h
Offset: 2-3 h
After Effects: 3-6 h
Insufflated
Dosage
Threshold: 2 mg
Light: 5-10 mg
Common: 10-20 mg
Strong: 20-35 mg
Heavy: 50-80 mg
Duration
Onset: 0.08-0.25 h
Comeup: 0.5-1.5 h
Peak: 1.5-3 h
Offset: 1.5-3 h
After Effects: 4-12 h
Oral (Extended Release)
Dosage
Threshold: 5 mg
Light: 5-15 mg
Common: 15-30 mg
Strong: 30-50 mg
Heavy: 50 mg
Duration
Onset: 0.5-1 h
Comeup: 0.5-1.5 h
Peak: 4-7 h
Offset: 2-4 h
After Effects: 6-24 h
Oral (Immediate Release)
Dosage
Threshold: 5 mg
Light: 5-10 mg
Common: 10-25 mg
Strong: 25-40 mg
Heavy: 40 mg
Duration
Onset: 0.33-0.67 h
Comeup: 0.5-1 h
Peak: 2.5-4 h
Offset: 2-3 h
After Effects: 4-12 h
Rectal (Dissolved Solution)
Dosage
Threshold: 2.5 mg
Light: 2.5-10 mg
Common: 10-20 mg
Strong: 20-30 mg
Heavy: 30 mg
Duration
Onset: 0.08-0.33 h
Comeup: 0.25-0.5 h
Peak: 2-3 h
Offset: 1.5-2.5 h
After Effects: 4-12 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
