Library
Fen-Phen
Daily Fen-Phen use was linked to valvular heart disease and pulmonary hypertension via 5-HT2B receptor agonism by fenfluramine's metabolite norfenfluramine; the combination was withdrawn from market in 1997. Nearly 30% of users taking the combination for up to 24 months developed abnormal valve findings. Phentermine alone does not cause valvular damage and remains available for short-term obesity treatment.
Also known as: Phen/fen, Phentermine + fenfluramine, Pondimin + phentermine, Adipex-P + Pondimin
Classification
- Chemical: Amphetamine
- Chemical: Phenethylamine
- Psychoactive: Depressant
- Psychoactive: Stimulant
- Tag: Habit-Forming
- Tag: Withdrawn
Effects
- Stimulation
- Sedation
- Tachycardia
- Dry Mouth
- Restlessness
- Insomnia
- Wakefulness
- Motivation Enhancement
- Euphoria
- Anxiety
- Vivid Dreams
- Cognitive Euphoria
- Appetite Suppression
- Light Sensitivity
- Dulled Perception
- Internal Hallucination
- Size Distortion
- Warmth
Routes of Administration
Oral
Dosage
- Threshold: 5/10 mg
- Light: 5-15 / 10-30 mg
- Common: 15-30 / 30-60 mg
- Strong: 30-37.5 / 60-80 mg
- Heavy: 45 mg+ / 80 mg+ (not recommended)
Duration
- Onset: 0.33-1 h
- Comeup: 0.5-1 h
- Peak: 1-3 h
- Offset: 3-6 h
- After Effects: 4-12 h
- Total Duration: 6-12 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
Links
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