Due to a sub-microgram active range, ordinary analytical balances cannot measure a non-lethal dose; volumetric dilution under inert atmosphere is essential. Naloxone may require large, repeated boluses because of lofentanil's long receptor residence time. This is one of the most potent opioids known, approximately 6000 times more potent than morphine, and has an extremely long duration of action compared to other fentanyl analogs.
Lofentanyl molecular structure diagram from the DrugsPRO substance library.
Also known as: R-32792, R-34995, 3-methyl-4-carbomethoxyfentanyl, Levo-cis-3-methylcarfentanil, 3-methylcarfentanil
Classification
Chemical: Anilidopiperidine
Chemical: Opioid
Psychoactive: Depressant
Tag: Anilinopiperidine
Tag: Habit-Forming
Tag: Research-Chemical
Tag: Sedative
Effects
Pain Relief
Physical Euphoria
Sedation
Respiratory Depression
Itchiness
Nausea
Cognitive Euphoria
Anxiety Suppression
Compulsive Redosing
Euphoria
Sadness
Dissociation
Dulled Perception
Open Eye Visuals
Sound Dampening
Routes of Administration
Intravenous
Dosage
Threshold: 0.1 µg (anecdotal)
Light: 0.1–0.3 µg (anecdotal)
Common: 0.3–1 µg (anecdotal)
Strong: 1–2 µg (anecdotal)
Heavy: ≥2 µg (rapidly lethal; do not attempt)
Duration
Onset: 0.01-0.03 h
Peak: 0.17-0.5 h
Offset: 4-6 h
After Effects: 2-6 h
Total Duration: 4-12 h
Intranasal
Dosage
Threshold: 0.2 ug
Light: 0.2-0.6 ug
Common: 0.6-1.5 ug
Strong: 1.5-3 ug
Heavy: 3 ug
Duration
Onset: 0.08-0.17 h
Peak: 0.17-0.5 h
Offset: 4-6 h
After Effects: 2-6 h
Insufflated
Dosage
Heavy: ≥3 µg (do not attempt)
Light: 0.2–0.6 µg (anecdotal)
Common: 0.6–1.5 µg (anecdotal)
Strong: 1.5–3 µg (anecdotal)
Threshold: 0.2 µg (anecdotal)
Duration
Onset: 5-15 h
Peak: 15-60 h
Offset: 240-480 h
After Effects: 120-360 h
Total Duration: 360-720 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
This static page is intended as a readable non-JS and prerender-friendly library export.
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Lofentanil - przewodnik po substancji DrugsPRO
Lofentanil: Due to a sub-microgram active range, ordinary analytical balances cannot measure a non-lethal dose; volumetric dilution under inert atmosphere is essential. Naloxone may require large, repeated boluses because of lofentanil's long receptor residence time. This is one of the most potent o
