MEAI, also known as 5-methoxy-2-aminoindane (5-MeO-AI) and by its developmental code name CMND-100, is an entactogen-like psychoactive drug of the 2-aminoindane family. It is a cyclized phenethylamine and is the 2-aminoindane analogue of 3-methoxyamphetamine. The drug acts as a serotonin–norepinephrine releasing agent (SNRA) or as a modestly selective serotonin releasing agent (SSRA), with about 6-fold preference for induction of serotonin over norepinephrine release. MEAI has been encountered as a novel designer recreational drug. It is also under development for potential medical use in the treatment of alcoholism, cocaine use disorder, metabolic syndrome, and obesity.
MEAI molecular structure diagram from the DrugsPRO substance library.
Also known as: 5-methoxy-2-aminoindane, 5-MeO-AI, CMND-100, 5-Methoxy-2-indanamine
Classification
Chemical: Aminoindane
Chemical: Phenethylamine
Psychoactive: Entactogen
Psychoactive: Stimulant
Effects
Increased Heart Rate
Stimulation
Insomnia
Jaw Tension
Teeth Grinding
Pain Relief
Talkativeness
Alertness Enhancement
Euphoria
Anxiety
Wakefulness
Irritability
Light Sensitivity
Appetite Suppression
Increased Libido
Dehydration
Open Eye Visuals
Increased Music Appreciation
Routes of Administration
No route information available yet.
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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MEAI - przewodnik po substancji DrugsPRO
MEAI: MEAI, also known as 5-methoxy-2-aminoindane (5-MeO-AI) and by its developmental code name CMND-100, is an entactogen-like psychoactive drug of the 2-aminoindane family. It is a cyclized phenethylamine and is the 2-aminoindane analogue of 3-methoxyamphetamine. The drug acts as a serotonin–norep