Methylphenidate is a central nervous system stimulant of the phenidate class. First synthesized in 1944, it became one of the most widely prescribed medications for attention deficit hyperactivity disorder (ADHD) and narcolepsy, marketed under brands such as Ritalin and Concerta. Outside clinical settings, it is used recreationally and as a cognitive enhancer, though its stimulant and euphoric effects are generally considered less pronounced than those of amphetamines.
Metylofenidat molecular structure diagram from the DrugsPRO substance library.
Also known as: Mph, R-ball, Skippy, Ritalin, Concerta, Metadate, Methylin, Aptensio XR, Jornay PM, Quillivant/QuilliChew, Relexxii, Riphenidate, Rubifen SR, Methylphenidat
Classification
Chemical: Medicine
Chemical: Phenidate
Psychoactive: Stimulant
Tag: Common
Tag: Habit-Forming
Tag: Phenylpiperidine
Tag: substituted phenidate
Effects
Stimulation
Increased Heart Rate
Increased Perspiration
Increased Alertness
Reduced Appetite
Flushing Of The Face
Euphoria
Focus Enhancement
Wakefulness
Memory Enhancement
Thought Acceleration
Analysis Enhancement
Dehydration
Appetite Suppression
Visual Trails
Increased Sexuality
Increased Music Appreciation
Visual And Auditory Hallucinations
Routes of Administration
Oral
Dosage
Heavy: 80-100 mg
Light: 5 – 15 mg
Common: 15 – 35 mg
Strong: 35 – 60 mg
Threshold: 2.5 mg
Duration
Onset: 0.5-1 h
Comeup: 0.33-0.75 h
Peak: 1-1.5 h
Offset: 0.75-1 h
After Effects: 2-6 h
Total Duration: 4-6 h
Insufflated
Dosage
Heavy: 60-75 mg
Light: 2 – 10 mg
Common: 10 – 30 mg
Strong: 30 – 60 mg
Threshold: 2 mg
Duration
Onset: 0.083-0.25 h
Comeup: 0.25-0.67 h
Peak: 0.5-0.75 h
Offset: 1.5-3.5 h
After Effects: 1-4 h
Total Duration: 2-5 h
Oral (Extended Release)
Dosage
Heavy: 80-100 mg
Light: 5 – 15 mg
Common: 15 – 35 mg
Strong: 35 – 60 mg
Threshold: 5 mg
Duration
Onset: 0.5-1 h
Comeup: 0.5-1 h
Peak: 4-8 h
Offset: 2-3 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Methylphenidate - przewodnik po substancji DrugsPRO
Methylphenidate: Methylphenidate is a central nervous system stimulant of the phenidate class. First synthesized in 1944, it became one of the most widely prescribed medications for attention deficit hyperactivity disorder (ADHD) and narcolepsy, marketed under brands such as Ritalin and Concerta. Ou
