O-PCE is a lesser-known novel dissociative of the arylcyclohexylamine class that produces dissociative, anesthetic, stimulating, and hallucinogenic effects, speculated to act primarily as an NMDA receptor antagonist. Structurally related to other arylcyclohexylamines like MXE and deschloroketamine, it emerged as a contemporary designer drug marketed through online research chemical vendors as a replacement for MXE and other dissociatives. It is reportedly habit-forming, and its pharmacological profile remains poorly characterized.
Also known as: 2-dcnek, 2-oxo-pce, Eticyclidone, N-ethyldeschloroketamine, Deschloro-n-ethyl-ketamine, Eticyclidon, Deschloro-N-ethylketamin
Classification
Chemical: Arylcyclohexylamine
Psychoactive: Dissociative
Tag: Habit-Forming
Tag: Hallucinogen
Tag: Research-Chemical
Tag: Tentative
Effects
Physical Euphoria
Pain Relief
Physical Disconnection
Stimulation
Numbness
Elevated Heart Rate
Compulsive Redosing
Time Distortion
Delusion
Euphoria
Memory Suppression
Ego Dissolution
Disinhibition
Perception Of Bodily Lightness
Spatial Disorientation
Auditory Distortion
Tactile Suppression
Double Vision
Routes of Administration
Oral
Dosage
Heavy: 40+ mg
Light: 1 – 5 mg
Common: 5 – 10 mg
Strong: 10 – 20 mg
Threshold: 1 mg
Duration
Onset: 0.33-0.67 h
After Effects: 4-48 h
Peak: 2-4 h
Offset: 4-8 h
Total Duration: 3-8 h
Insufflated
Dosage
Heavy: 30+ mg
Light: 2 – 6 mg
Common: 6 – 12 mg
Strong: 12 – 20 mg
Threshold: 2–3 mg
Duration
Onset: 0.25-0.75 h
After Effects: 2-12 h
Peak: 1-3 h
Offset: 3-5 h
Total Duration: 2-5 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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O-PCE - przewodnik po substancji DrugsPRO
O-PCE: O-PCE is a lesser-known novel dissociative of the arylcyclohexylamine class that produces dissociative, anesthetic, stimulating, and hallucinogenic effects, speculated to act primarily as an NMDA receptor antagonist. Structurally related to other arylcyclohexylamines like MXE and deschloroket
