PRE-084

A sigma-1 receptor agonist derived structurally from PCP. It has cognitive enhancing effects as well as antidepressant effects, and shows promise in treating many nervous system diseases such as ALS and parkinsons.

Also known as: Research ligand PRE-084

Classification

Psychoactive: Depressant
Tag: Tentative

Effects

Stimulation
Insomnia
Sedation
Motor Impairment
Increased Focus
Euphoria
Reduced Anxiety
Dulled Perception

Routes of Administration

Oral

Dosage

Heavy: 60+ mg
Light: 2–10 mg
Common: 10–30 mg
Strong: 30–60 mg
Threshold: 1–2 mg

Duration

Onset: 0.25-0.75 h
Peak: 1-2 h
Offset: 2-3 h
After Effects: 3-5 h
Total Duration: 3-5 h

Sublingual

Dosage

Heavy: 60+ mg
Light: 2–10 mg
Common: 10–30 mg
Strong: 30–60 mg
Threshold: 1–2 mg

Duration

Onset: 0.25-0.5 h
Peak: 1-2 h
Offset: 2-3 h
After Effects: 3-5 h
Total Duration: 3-5 h

Insufflated

Dosage

Heavy: 40+ mg
Light: 2–8 mg
Common: 8–20 mg
Strong: 20–40 mg
Threshold: 1–2 mg

Duration

Onset: 0.08-0.25 h
Peak: 0.75-1.5 h
Offset: 1.5-2.5 h
After Effects: 2.5-4 h
Total Duration: 3-4 h

Harm Reduction

Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.

Sources

Substance data is aggregated from the following public harm-reduction and reference sources.

tripsit.me

Links

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PRE-084

Classification

Effects

Routes of Administration

Oral

Sublingual

Insufflated

Harm Reduction

Sources

Links

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