TMA is a rare synthetic psychedelic amphetamine and the alpha-methylated analog of mescaline. Effects are generally less visual and less euphoric than mescaline, with more unpredictable emotional responses. At higher doses (above 200 mg), Shulgin's research documented potentially antisocial behavioral changes including anger and hostility, which were not observed with mescaline. Effects include mild psychedelic aura, tactile enhancement, and dreamy mental states with minimal visuals at lower doses. There is extremely limited human use history and virtually no modern research.
TMA molecular structure diagram from the DrugsPRO substance library.
Also known as: Tma-1, 3,4,5-tma, Α-methylmescaline, Mescalamphetamine, Trimethoxyamphetamine
Classification
Chemical: Amphetamine
Chemical: Phenethylamine
Psychoactive: Psychedelic
Psychoactive: Stimulant
Tag: Hallucinogen
Tag: Research-Chemical
Effects
Nausea
Pupil Dilation
Increased Heart Rate
Stimulation
Coldness
Insomnia
Emotion Enhancement
Cognitive Euphoria
Conceptual Thinking
Anxiety
Time Distortion
Introspection
Tactile Enhancement
Visual Patterning
Color Enhancement
Open Eye Visuals
Light Sensitivity
Tracers
Routes of Administration
Oral
Dosage
Threshold: 50-80 mg
Light: 80-120 mg
Common: 120-180 mg
Strong: 180-225 mg
Heavy: 250+ mg
Duration
Onset: 1.5-2 h
Comeup: 0.5-1 h
Peak: 3-5 h
Offset: 2-3 h
After Effects: 8-14 h
Total Duration: 6-8 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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TMA - przewodnik po substancji DrugsPRO
TMA: TMA is a rare synthetic psychedelic amphetamine and the alpha-methylated analog of mescaline. Effects are generally less visual and less euphoric than mescaline, with more unpredictable emotional responses. At higher doses (above 200 mg), Shulgin's research documented potentially antisocial beh