Estradiol is used in two primary contexts: (1) Menopausal hormone replacement therapy for cisgender women at lower doses (0.5-2mg oral), and (2) Gender-affirming feminizing hormone therapy for transgender women at moderate-to-high doses (4-8mg+ oral, or 4-10mg weekly injectable monotherapy). For menopausal use, prescribe at the lowest effective dose for shortest duration necessary. When prescribed to individuals with an intact uterus, progestin co-administration reduces endometrial hyperplasia risk. For gender-affirming care, adequate testosterone suppression is the primary goal; many require 6-8mg oral or injectable monotherapy. Contraindicated in estrogen-dependent tumors, active thromboembolic disorders, undiagnosed vaginal bleeding, and pregnancy.
Estradiol molecular structure diagram from the DrugsPRO substance library.
Also known as: E2, Oestradiol, Β-estradiol, 17β-estradiol, Estrogen therapy, Estradiol-17β, Cis-Estradiol, Estradiol Cypionate
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Estradiol - Guia de substâncias DrugsPRO
Estradiol: Estradiol is used in two primary contexts: (1) Menopausal hormone replacement therapy for cisgender women at lower doses (0.5-2mg oral), and (2) Gender-affirming feminizing hormone therapy for transgender women at moderate-to-high doses (4-8mg+ oral, or 4-10mg weekly injectable monotherap
