Library
MD-PiHP
In vitro transporter panels show MD-PiHP to be a potent DAT/NET blocker with ~10-fold selectivity over SERT, sitting pharmacologically between α-PiHP and MDPHP. User reports indicate functional stimulation at 5-15 mg insufflated but marked vasoconstriction, bruxism and body-load over 40 mg. Vaping the HCl salt is heat-sensitive: freebasing or very low flame/oil-burner technique is essential to avoid pyrolysis. Oral dosing produces a flatter, long-tail stimulation (up to 8-10 hours wakefulness) that many find more manageable. Binge patterns exceeding 500 mg/24 hours have precipitated stimulant psychosis with auditory hallucinations, paranoia and formication; strict session caps (under 100 mg/day) and 48-hour recovery windows are strongly advised.
Also known as: 3,4-methylenedioxy-pihp
Classification
- Chemical: Cathinone
- Psychoactive: Stimulant
- Tag: Pyrrolidine
- Tag: Research-Chemical
Effects
- Stimulation
- Teeth Grinding
- Nystagmus
- Vasoconstriction
- Jaw Tension
- Coldness
- Euphoria
- Focus Enhancement
- Motivation Enhancement
- Compulsive Redosing
- Thought Acceleration
- Wakefulness
- Increased Libido
- Disinhibition
- Appetite Suppression
- Light Sensitivity
- Dehydration
- Tactile Enhancement
Routes of Administration
Insufflated
Dosage
- Threshold: 2mg mg
- Light: 2mg - 10mg mg
- Common: 10mg - 30mg mg
- Strong: 30mg - 45mg mg
- Heavy: 45+ mg
Duration
- Onset: 0.02-0.05 h
- Comeup: 0.08-0.25 h
- Peak: 0.1-1 h
- Offset: 1-3 h
- After Effects: 2-12 h
- Total Duration: 2-5 h
Oral / Sublingual
Dosage
- Threshold: 5 mg
- Light: 5-20 mg
- Common: 20-50 mg
- Strong: 50-80 mg
- Heavy: 80 mg
Duration
- Onset: 0.25-0.5 h
- Comeup: 0.5-1 h
- Peak: 1-3 h
- Offset: 2-4 h
- After Effects: 4-12 h
Vaporized / Smoked (Freebase)
Dosage
- Threshold: 1 mg
- Light: 1-5 mg
- Common: 5-20 mg
- Strong: 20-40 mg
- Heavy: 40 mg
Duration
- Onset: 0.01-0.03 h
- Comeup: 0.02-0.08 h
- Peak: 0.25 h
- Offset: 1-2 h
- After Effects: 2-12 h
Rectal
Dosage
- Threshold: 3mg mg
- Light: 3mg - 10mg mg
- Common: 10mg - 25mg mg
- Strong: 25mg - 40mg mg
- Heavy: 40+ mg
Duration
- Onset: 0.08-0.25 h
- Comeup: 0.25-0.5 h
- Peak: 1-2 h
- Offset: 1-3 h
- After Effects: 2-12 h
Intravenous
Dosage
- Threshold: 1mg mg
- Light: 1mg - 5mg mg
- Common: 5mg - 15mg mg
- Strong: 15mg - 30mg mg
- Heavy: 30+ mg
Duration
- Onset: 0.01-0.03 h
- Comeup: 0.02-0.05 h
- Peak: 0.25 h
- Offset: 1-2 h
- After Effects: 2-12 h
Oral
Dosage
- Heavy: 80+ mg
- Light: 5mg - 20mg mg
- Common: 20mg - 50mg mg
- Strong: 50mg - 80mg mg
- Threshold: 5mg mg
Duration
- Onset: 0.25-0.75 h
- Peak: 0.5-2 h
- Offset: 2-5 h
- After Effects: 5-12 h
- Total Duration: 3-8 h
Sublingual
Dosage
- Heavy: 70+ mg
- Light: 5mg - 15mg mg
- Common: 15mg - 40mg mg
- Strong: 40mg - 70mg mg
- Threshold: 5mg mg
Duration
No data available for this section yet.
Vaporized
Dosage
- Heavy: 40+ mg
- Light: 1mg - 5mg mg
- Common: 5mg - 20mg mg
- Strong: 20mg - 40mg mg
- Threshold: 1mg mg
Duration
- Onset: 0.008-0.03 h
- Peak: 0.05-0.75 h
- Offset: 0.75-2 h
- After Effects: 2-10 h
- Total Duration: 1.5-4 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
Links
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