MEAI, also known as 5-methoxy-2-aminoindane (5-MeO-AI) and by its developmental code name CMND-100, is an entactogen-like psychoactive drug of the 2-aminoindane family. It is a cyclized phenethylamine and is the 2-aminoindane analogue of 3-methoxyamphetamine. The drug acts as a serotonin–norepinephrine releasing agent (SNRA) or as a modestly selective serotonin releasing agent (SSRA), with about 6-fold preference for induction of serotonin over norepinephrine release. MEAI has been encountered as a novel designer recreational drug. It is also under development for potential medical use in the treatment of alcoholism, cocaine use disorder, metabolic syndrome, and obesity.
MEAI molecular structure diagram from the DrugsPRO substance library.
Also known as: 5-methoxy-2-aminoindane, 5-MeO-AI, CMND-100, 5-Methoxy-2-indanamine
Classification
Chemical: Aminoindane
Chemical: Phenethylamine
Psychoactive: Entactogen
Psychoactive: Stimulant
Effects
Increased Heart Rate
Stimulation
Insomnia
Increased Perspiration
Nausea
Temporary Erectile Dysfunction
Talkativeness
Alertness Enhancement
Anxiety
Euphoria
Focus Enhancement
Thought Acceleration
Light Sensitivity
Appetite Suppression
Increased Music Appreciation
Dehydration
Tactile Enhancement
Open Eye Visuals
Routes of Administration
No route information available yet.
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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MEAI - Guia de substâncias DrugsPRO
MEAI: MEAI, also known as 5-methoxy-2-aminoindane (5-MeO-AI) and by its developmental code name CMND-100, is an entactogen-like psychoactive drug of the 2-aminoindane family. It is a cyclized phenethylamine and is the 2-aminoindane analogue of 3-methoxyamphetamine. The drug acts as a serotonin–norep