5-APDI (IAP) is a potent but weakly selective serotonin-releasing agent with IC50 values of 82 nM for serotonin, 1,848 nM for dopamine, and 849 nM for norepinephrine. Users report empathogenic warmth, mental stimulation, and occasionally mild visuals, but also pronounced body-load including hyperthermia, profuse sweating, bowel urgency, bruxism, and insomnia. Onset is slow; premature redosing has produced serotonin syndrome-like reactions. Cardiovascular stress and unpredictable individual response make conservative titration and external temperature control essential. Milligram-scale weighing and reagent testing are strongly advised.
Also known as: Iap, 2-api, Indanametamine, Indanylaminopropane, Indanylaminopropane, indanylamphetamine, 5-apdi, 5-iap, Indanylamphetamine, 5-IAP
Classification
Chemical: Aminoindane
Chemical: Amphetamine
Psychoactive: Entactogen
Psychoactive: Psychedelic
Psychoactive: Stimulant
Tag: Empathogen
Tag: Research-Chemical
Tag: Tentative
Effects
Stimulation
Teeth Grinding
Gastrointestinal Discomfort
Diarrhea
Excessive Perspiration
Pupil Dilation
Euphoria
Increased Sociability
Empathy Enhancement
Anxiety
Mood Lift
Excessive Talking
Music Enhancement
Visual Enhancement
Tracers
Increased Sexuality
Visual And Audiotory Hallucinations Itchiness
Increased Music Appreciation
Routes of Administration
Oral
Dosage
Threshold: 10 mg
Light: 15-25 mg
Common: 25-50 mg
Strong: 50-75 mg
Heavy: 75+ mg
Duration
Onset: 0.5-1.5 h
Peak: 2-5 h
Offset: 3-6 h
After Effects: 1-6 h
Total Duration: 8-14 h
Insufflated
Dosage
Threshold: 5 mg
Light: 5-10 mg
Common: 10-20 mg
Strong: 20-30 mg
Heavy: 30+ mg
Duration
Onset: 0.08-0.25 h
Peak: 2-4 h
Offset: 2-4 h
After Effects: 1-6 h
Total Duration: 6-12 h
Intravenous
Dosage
Threshold: 2 mg
Light: 3-5 mg
Common: 5-10 mg
Strong: 10-15 mg
Heavy: 15+ mg
Duration
Onset: 0.02-0.08 h
Peak: 2-4 h
Offset: 2-4 h
After Effects: 1-6 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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5-APDI - Ghid de substanțe DrugsPRO
5-APDI: 5-APDI (IAP) is a potent but weakly selective serotonin-releasing agent with IC50 values of 82 nM for serotonin, 1,848 nM for dopamine, and 849 nM for norepinephrine. Users report empathogenic warmth, mental stimulation, and occasionally mild visuals, but also pronounced body-load including
