DOI

DOI is a psychedelic amphetamine of the DOx family. First described in the scientific literature in 1973, it was later documented in detail by Alexander Shulgin in PiHKAL (1991). DOI is among the most potent phenethylamine psychedelics and is notable for its exceptionally long duration, which can prevent sleep for 24 hours or more. It is widely used in scientific research as a radioligand for mapping serotonin 5-HT2A receptors in the brain.

DOI molecular structure diagram from the DrugsPRO substance library.

Classification

Chemical: Amphetamine
Chemical: Phenethylamine
Psychoactive: Psychedelic
Psychoactive: Stimulant
Tag: Hallucinogen
Tag: Research-Chemical
Tag: Substituted amphetamine

Effects

Spontaneous Tactile Sensations
Stimulation
Nausea
Increased Heart Rate
Pupil Dilation
Mentalphysical Stimulation
Empathy Love And Sociability Enhancement
Analysis Enhancement
Time Distortion
Novelty Enhancement
Emotion Enhancement
Immersion Enhancement
Increased Libido
Bodily Control Enhancement
Tactile Enhancement
Hallucinations
Drifting
Tracers

Routes of Administration

Oral

Dosage

Heavy: 750 mg
Light: 0.75-1 mg
Common: 1-3 mg
Strong: 750 mg
Threshold: 0.5-0.75 mg

Duration

Onset: 1-2 h
Comeup: 1.5-3 h
After Effects: 1-24 h

Harm Reduction

Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.

Sources

Substance data is aggregated from the following public harm-reduction and reference sources.

Links

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DOI