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AEM is an extremely rare and poorly documented phenethylamine psychedelic first synthesized by Alexander Shulgin and described in PiHKAL as entry #1. Shulgin reported that doses exceeding 220 mg produced few to no psychoactive effects, classifying it as essentially inactive. The compound's inactivity discouraged Shulgin from synthesizing further alpha-position-extended mescaline analogues (such as alpha-propylmescaline or alpha-butylmescaline). Research in rodents suggests these extended homologues are non-hallucinogenic. Due to the complete lack of human psychoactive data and unknown safety profile, AEM should be considered an inactive research chemical with no established use case.

Also known as: Α-ethylmescaline, Α-ethyl-3,4,5-trimethoxyphenethylamine, Alpha-Ethylmescaline

Classification

Chemical: Phenethylamine
Tag: Inactive
Tag: Research-Chemical
Tag: Scaline

Effects

No Significant Psychoactive Effects Reported

Routes of Administration

Oral

Dosage

Threshold: No activity observed up to 220 mg (sub‑threshold testing only)

Duration

No data available for this section yet.

Harm Reduction

Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.

Sources

Substance data is aggregated from the following public harm-reduction and reference sources.

dose.wiki

Links

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