Etoxadrol is a dioxolane NMDA antagonist developed as a dissociative anesthetic; unlike arylcyclohexylamines (PCP/ketamine), it features a 1,3-dioxolane piperidine scaffold. Clinical work shows IV 0.75 mg/kg yields anesthesia averaging 26 minutes (14-53 minutes) with active airway reflexes but raised heart rate/blood pressure and tachypnea. Prominent post-dose phenomena include alternating nystagmus lasting hours and vivid dream-like states; approximately 20% of patients reported unpleasant or threatening dreams persisting up to 24 hours. One overdose case at 4.65 mg/kg caused catalepsy, amnesia, and analgesia lasting 6 days. Binding studies place etoxadrol as a high-affinity PCP-site channel blocker at NMDA receptors (Ki = 107 nM), explaining PCP-like behavioral effects and animal self-administration.
Этоксадрол molecular structure diagram from the DrugsPRO substance library.
Also known as: Cl-1848c, U-37862a
Classification
Psychoactive: Dissociative
Tag: Dioxolane piperidine dissociative
Tag: Hallucinogen
Tag: Other dissociative
Tag: Research-Chemical
Effects
Analgesia
Nystagmus
Tachycardia
Nausea
Pain Relief
Vomiting
Amnesia
Dissociation
Depersonalization
Time Distortion
Confusion
Anxiety
Dreamlike Imagery
Tactile Suppression
Double Vision
Open Eye Visuals
Visual Disconnection
Disinhibition
Routes of Administration
Intravenous (Clinical Use only)
Dosage
Threshold: ~0.2 mg/kg
Light: 0.3-0.5 mg/kg
Common: 0.6-0.9 mg/kg
Strong: 1.0-1.5 mg/kg
Heavy: 2.0 mg/kg
Duration
Offset: 0.25-1 h
After Effects: 18-24 h
Intravenous
Dosage
Heavy: ≥2.0 mg/kg
Light: 0.3–0.5 mg/kg
Common: 0.6–0.9 mg/kg
Strong: 1.0–1.5 mg/kg
Threshold: ~0.2 mg/kg
Duration
Onset: 0.1-1 h
Peak: 0-10 h
Offset: 15-60 h
After Effects: 60-1440 h
Total Duration: 14-53 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Etoxadrol - гид по веществам DrugsPRO
Etoxadrol: Etoxadrol is a dioxolane NMDA antagonist developed as a dissociative anesthetic; unlike arylcyclohexylamines (PCP/ketamine), it features a 1,3-dioxolane piperidine scaffold. Clinical work shows IV 0.75 mg/kg yields anesthesia averaging 26 minutes (14-53 minutes) with active airway reflexe
