Chloralhydrát

Chloral hydrate is one of the oldest sedative-hypnotics, first synthesized in 1832. It has a very narrow therapeutic window and overdose can cause severe respiratory depression, cardiac arrhythmias, coma, and death. Chronic use can lead to liver damage and rapid tolerance development. Combination with alcohol (creating a Mickey Finn) is especially dangerous. Discontinued in the US in 2012 but still available in some countries.

Also known as: Noctec, Somnos, Somnote, Welldorm, Mickey finn, Aquachloral, Knockout drops, Trichloroacetaldehyde monohydrate

Classification

Chemical: Medicine
Psychoactive: Depressant
Tag: GABAergic
Tag: Habit-Forming
Tag: Sedative

Effects

Sedation
Muscle Relaxation
Physical Euphoria
Respiratory Depression
Incoordination
Numbness
Motor Control Loss
Amnesia
Dizziness
Anxiety Suppression
Drowsiness
Euphoria
Disinhibition
Dulled Perception

Routes of Administration

Oral

Dosage

Threshold: 250 mg
Light: 250-500 mg
Common: 500–1,000 mg
Strong: 500 mg
Heavy: 500+ mg

Duration

Onset: 0.33-1 h
Peak: 1-2 h
Offset: 2-6 h
After Effects: 6-24 h
Total Duration: 4-8 h

Rectal

Dosage

Threshold: 250 mg
Light: 250-500 mg
Common: 500–1,000 mg
Strong: 500 mg
Heavy: 500+ mg

Duration

Onset: 0.25-0.75 h
Peak: 1-2 h
Offset: 2-6 h
After Effects: 24 h

Harm Reduction

Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.

Sources

Substance data is aggregated from the following public harm-reduction and reference sources.

Links

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